Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease. Thus, Naip5 has been suggested to regulate Legionella replication inside macrophages through the activation of caspase-1. In this study, we show that cytosolic delivery of recombinant...

BACKGROUND Whole body ischemia-reperfusion injury (IRI) after cardiopulmonary resuscitation (CPR) induces a generalized inflammatory response which contributes to the development of post-cardiac arrest syndrome (PCAS). Recently, pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and inflammasomes, have been shown to mediate the inflammatory response in IRI. In this study w...

The NLRP3 inflammasome is a caspase-1 containing multi-protein complex that controls the release of IL-1β and plays important roles in innate immune response. Since implicated pathogenesis variety diseases, it has become an increasingly interested target developing therapies for multiple diseases. We reported current study to determine how luteolin, natural phenolic compound found many vegetabl...

Ilex cornuta Leaves (ICLs) are a representative and traditional prescription for controlling obesity. Nevertheless, the corresponding therapeutic compounds related pharmacological mechanisms of such medication remain undocumented. The from ICLs were identified by gas chromatography-mass spectrum (GC-MS), SwissADME confirmed their physicochemical properties. Next, target proteins to or obesity-a...

The NOD-like receptor P3 (NLRP3) inflammasome is an intracellular multimeric complex that triggers the activation of inflammatory caspases and the maturation of IL-1β and IL-18, important cytokines for the innate immune response against pathogens. The functional NLRP3 inflammasome complex consists of NLRP3, the adaptor protein apoptosis-associated speck-like protein, and caspase-1. Various mole...

Abstract The Casparian strip (CS) constitutes a physical diffusion barrier to water and nutrients in plant roots, which is formed by the polar deposition of lignin polymer endodermis tissue. precise pattern determined scaffolding activity membrane-bound Strip domain proteins (CASPs), but little known mechanism(s) directing this process. Here, we demonstrate that Endodermis-specific Receptor-lik...