introduction: postoperative neurological deficit is the most devastating complication after thoracoabdominal aortic aneurysm repair. despite demonstrated neuroprotective effects of estradiol, its protective efficacy against spinal cord ischemia-reperfusion and underlying mechanisms are not yet elucidated. methods: two groups, each of 10 new zealand white male rabbits, were studied. control grou...

Apoptosis, programmed cell death, has a central role in developmental biology and maintaining the equilibrium of renewing tissues. A founding member Bcl-2 family regulatory proteins for apoptosis is Bcl-2, which encoded by BCL2 gene. Caspase-3 shares typical features with all caspases, including acting as crucial mediator apoptosis.

The present study investigated the possible protective effects of melatonin on Bleomycin, Cisplatin and etoposide (BEP) chemotherapy regimens using immunohistochemistry. Forty male Wistar rats were divided into four groups ten as; group 1 as untreated control; 2 BEP which received three cycles 21 days’ regimen each 0.5¥ dose levels ofBEP (bleomycin 0.75 mg/kg, 7.5 mg/kg cisplatin 1.5 mg/kg)....

The aim of this study was to investigate the possible role [99mTc]Tc-Sestamibi in regulation cancer cell proliferation and apoptosis. To end, vivo values uptake have been associated with in-situ expression both Ki67 caspase-3. For vitro investigations, BT-474 cells were incubated three different concentrations [99mTc]Tc-Sestamibi: 10 µg/mL, 1 0.1 µg/mL. Expression caspase-3 Ki67, as well ultras...