introduction: neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as alzheimer’s disease, parkinson’s disease and etc. gemfibrozil is used as a therapeutic drug for hyperlipidemia. it has been shown that gemfibrozil is neuroprotecti...

objective(s): renal cell carcinoma (rcc) is insensitive to conventional chemotherapy. ginkgetin effectively treats several carcinoma cells. however, little is known about effects of ginkgetin on rcc. in the present study, using 786-o cells, we evaluate whether ginkgetin exerts anticancer effects against rcc. materials and methods: 786-o cells suspended in the medium containing ginkgetin were cu...

To determine whether Smac/DIABLO (second mitochondrial activator of caspases/direct inhibitor of apoptosis protein-binding protein of low isoelectric point [PI]) and XIAP (X-chromosome-linked inhibitor of apoptosis protein) serve to regulate neuronal apoptosis following seizures, we investigated seizure-induced changes in caspase-9, Smac/DIABLO and XIAP protein expression and the in vivo effect...

Background and Aim: Smoking has been extensively investigated in oncology, controversial associations with brain tumor incidence have reported. Caspase-3 matrix metalloproteinases (MMPs) belong to an important cascade vasculogenesis. We aim study the smoking impact on these signaling molecules nontumoral rat tissue. Methods Materials/Patients: A total of 60 Wistar rats were divided into two gro...

Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) are believed to exacerbate symptoms and inflammation in patients with inflammatory bowel disease (IBD). Recent studies indicate the gut microbiota may play a role NSAID-promoted inflammation. However, mechanism(s) underpinning NSAID-induced not fully understood. In this study, using piroxicam-accelerated model of colitis (PAC) I...

Osteosarcoma is a highly malignant primary tumor on bone that mainly attacks children and young adolescents. Until now, osteosarcoma therapy still combines some high costs invasive modalities may give side effects, such as pain nausea. Our previous studies suggested non-contact electric field has anti-proliferative effect breast cancer cells, in vitro vivo. In this study, we were interested stu...

During programmed cell death (PCD) apoptosis is controlled by many factors such as proteases. With no specific protease (s) known during PCD in the developing nervous system so far, we sought to determine if any specific protease (s) is involved in this process and therefore used different protease inhibitors during PCD (from embryonic day 6 to 10) in chick embryos. Among the inhibitors commerc...