Changes in plasma von Willebrand factor concentration (VWF:Ag) and ADAMTS-13 activity (the metalloprotease that cleaves VWF physiologically) have been reported in several cardiovascular disorders with prognostic implications. We therefore determined the level of these proteins in the plasma of children with cyanotic congenital heart disease (CCHD) undergoing surgical treatment. Forty-eight chil...

BACKGROUND AND PURPOSE Brain abscess is an uncommon intracranial suppuration, especially in children. We reviewed the records of children with brain abscess admitted to Taipei Veterans General Hospital, Taipei, Taiwan, and analyzed data on presenting symptoms, predisposing factors and outcomes. METHODS Information was obtained retrospectively from medical records of children diagnosed with br...

OBJECTIVES To evaluate the effectiveness of critical congenital heart disease (CCHD) screening program for early diagnosis of cardiac anomalies in newborn infants.  Methods: This is a hospital-based prospective cross-sectional study conducted in the Pediatric and Neonatology Department, King Fahad Hospital at  Albaha, Saudi Arabia, between February 2016 and February 2017. Results: We screened 2...

OBJECTIVE To determine the etiology of Hilar malignant biliary strictures and the efficacy of hepaticojejunostomy in it's management with or without segmental liver resection. PATIENTS AND METHODS A retrospective study of 33 patients was carried out at Civil Hospital & Lyari General Hospital Karachi. They presented with signs and symptoms of mechanical cholestasis. Study was conducted to find...

A case-control study on chronic Chagas heart disease (CCHD) was carried out between 1997 and 2005. Ninety patients over 50 years of age were examined for factors related to (CCHD). Fourty-six patients (51.1%) with Chagas heart disease (anomalous ECG) were assigned to the case group and 44 (48.9%) were included in the control group as carriers of undetermined forms of chronic disease. Social, de...

Cyanotic congenital heart disease (CCHD) refers to a group of heart diseases which occur after birth, affect 1/1000 live newborns, and are associated with systemic hypoxia. The incidence of congenital heart disease ranges from 12 to 14/1000 live newborns.1 The different congenital cardiac defects may cause increased pulmonary vascular resistance and pulmonary hypertension, so that approximately...

BACKGROUND: Although newborn screening for critical congenital heart disease (CCHD) was recommended by the US Health and Human Services Secretary’s Advisory Committee on Heritable Disorders in Newborns and Children to promote early detection, it was deemed by the Secretary of the HHS as not ready for adoption pending an implementation plan from HHS agencies. OBJECTIVE: To develop strategies for...

Abstract Critical congenital heart diseases (CCHD) are important causes of mortality and morbidity in the newborn period. Even after diagnosis, their management could be seriously compromised by unplanned delivery hospitals with limited expertise resources. The may spend days or week before transport putting a significant burden on neonatal team to manage such challenging diseases. In this revi...