Effect of S-adenosyl-L-methionine disulfate tosylate salt (SAMe-ST) and L-methionine (L-Met) on primary cultured rat hepatocytes were studied. In cultured hepatocytes treated with CCl4, SAMe-ST and L-Met suppressed the decrease in urea-nitrogen secretion as well as the leakages of GOT and GPT. The membrane-protective action of these two compounds was verified by the histological data. Failure o...

Methanolic extract and fractions, ethylacetate (EtF) and butanol (BuF) of leaves of African mistletoe (Tapinanthus bangwensis, Engl. & K. Krause) were evaluated for their hepatoprotective potential using CCl4-induced hepatotoxicity in Wistar albino rats. The activities of the marker enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubi...

Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities of the both extracts against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Both extr...

This study was designed to investigate the potentially protective effects of Curcuma longa Linn. extract (CLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Male Sprague-Dawley rats were pretreated with 50 or 100mg/kg of CLE or 100mg/kg of butylated hydroxytoluene (BHT) for 14 days before CCl4 administration. In addition, the CLE control group was pretreated with 100mg/kg CLE f...

Hepatoprotective activity of the chloroform extract of the shade dried aerial parts of Solanum trilobatum Linn. was studied in wister rats using the CCl4 induced hepatotoxicity. The activity was evaluated by using biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase...

Several human diseases including, cancer, rheumatoid arthritis, neurodegenerative and hepatic diseases are related to destructive effect of reactive oxygen species (ROS). Antioxidants may provide a possible solution to this problem.This study was carried out to investigate the effect of hydroalcoholic extract of Celtis australis on CCl4 induced hepatotoxicity in mice.  The antioxidant activity...

The present study was conducted to evaluate the hepatoprotective activity of ethanolic leaf extract of Couroupita guianensis against CCL4 induced liver damage in rats. Anti-oxidant activity was evaluated by DPPH (2, 2-diphenyl-1-picrylhydrazyl) and hydrogen peroxide scavenging. Ascorbic acid was used as the standard antioxidants for comparison. Healthy male Wistar albino rats of either sex (150...