Lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; CCNU) is a synthetic orally active nitrosourea marketed in the past few years for the chemotherapy of carcinoma, particularly of the brain. The major toxic effects are bone marrow suppression with leucopenia and thrombocytopenia and gastrointestinal effects with nausea and vomiting. Progressive lung changes resulting from cytotoxic drugs ...

TO THE EDITOR: We read with interest the publication by Ater et al on the comparison between two different chemotherapy regimens for low-grade glioma in children. The primary aim was to compare the event-free survival but the stated secondary aims included a comparison of toxicity of the two regimens. The discussion mentions the fear that the TPCV (thioguanine, procarbazine, CCNU, vincristine) ...

Number Treatment NumberOfPatients PatientCatagory Outcome 13014 Accelerated RT/Temodar 28 New GBM mPFS=6m, PFS6=48%, OS1yr=48%, OS2yr=8%. 2051 AMG-102 20 Recurrent GBM Response rate = 30% 13010 Avastin + chemo 34 Recurrent GBM PSF6=25%, mTTP=4m, mOS=7.5m. 2021 Avastin + CPT-11 35 Recurrent GBM PFS6=43%, OS6=74%, 2yrOS=15%. 2023 Avastin + CPT-11 44 Recurrent GBM mPFS=5.2m, mOS=9.0m. 13000 Avasti...

determine the molecular basis for the cytotoxic action that produces the antitumor effect. Unfortunately, there is pres ently no direct way to identify with certainty the critical molecular lesions. It is, however, possible to obtain comrel ative evidence between molecular effects and cytotoxic effects in various cell types, which could lead to a probable identification of the critical lesions....

BACKGROUND Antiangiogenic treatment of glioblastomas with Bevacizumab lacks predictive markers. Myoinositol (MI) is an organic osmolyte, with intracellular concentration changes depending on the extracellular osmolality. Since Bevacizumab markedly reduces tumor edema and influences the tumor microenvironment, we investigated whether the MI concentration in the tumor changes during therapy. ME...

Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O6-alkylguanine-DNA alkyltransferase (AGT), ultimately leading to drug resistance. Therefore, the level of AGT expression ...