Sialic acid is the active site of neuraminidase protein, eventually it cleaves form its substrate via sialsyl cation intermediate and proliferates viral infection to other cells. On account weak binding affinity between receptor, communicates cells leads mortality humans. DANA first sialidase inhibitor formed by dehydration C2 hydroxyl group sialic acid. The replacement at C4 position an amino ...

Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible ligands are small nuclear (snRNA) endogenous retroviral elements (ERV) leaking from nucleus during programmed cell death.

Two types of angiotensin-converting enzyme (ACE) inhibitors, lisinopril and benazepril HCl, were tested in neuroblastoma cells found to upregulate low-density lipoprotein-receptor-related protein 1B (LRP1B) 14-3-3 zeta/delta. Additionally, HCl was increase the expression calreticulin. The upregulation these proteins by ACE inhibitors may contribute amelioration cognitive deficits Alzheimer’s di...

Inspired by the medicinal properties of plant Cannabis sativa and its principal component (?)- trans-? 9 -tetrahydrocannabinol (THC), researchers have developed a variety compounds to modulate endocannabinoid system in human brain. Inhibitors fatty acid amide hydrolase (FAAH) monoacylglycerol lipase (MAGL), which are enzymes responsible for inactivation endogenous cannabinoids anandamide 2-arac...

Major depressive disorder is a common emotional mood disease, which mainly manifests as depression, cognitive impairment, weakened volition activities, loss of appetite, and sleep disorders. Depression mental affecting more than 264 million people worldwide. There are many antidepressant drugs in clinic, e.g., tricyclic antidepressants, monoamine oxidase inhibitors, selective serotonin (5-HT) r...

Hormone therapy alone or in combination with targeted agents (CDK4/6 inhibitors, alpelisib, everolimus) is currently the standard treatment of metastatic luminal Her2-negative breast cancer. Aromatase inhibitors and fulvestrant are main hormone agents. Fulvestrant belongs to a special class antiestrogens – selective estrogen receptor degraders (SERD) does not have agonist activity, unlike tamox...

Coronaviruses (CoVs) are a group of viruses that induce infection in the respiratory and other systems in the human body. There are two coronaviruses that transmitted from animals to humans including severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) (1). The novel coronavirus that appeared at first in Wuhan, China, in December 2019 was named as severe acut...

The article analyzes the main clinical and theoretical data on features of treatment atrial fibrillation (AF) in combination with diabetes mellitus (DM). Differentiated approaches to correction these cardiac arrhythmias this category patients are considered, among which methods first choice hypoglycemic therapy catheter ablation. Currently, addition metformin, is basis for most type 2 diabetes,...

Aims: To find active compounds from natural ingredients that have the potential to be antivirals of SARS-CoV-2.
 Study Design: Simulation research.
 Place and Duration Study: Physics Laboratory, Department Education, Universitas Kristen Indonesia, between December 2021 August 2022.
 Methodology: The method used is a computational simulation commonly known as docking or molecular ...