Abstract This update of the Cromer (CROM) blood group system (Storry JR, Reid ME, Yazer MH. The system: a review. Immunohematology 2010;26:109–17) includes additional variants to (ISBT021), both new antigens and molecular bases underlying null phenotype. molecule on which are carried, CD55 (DAF), is an important receptor for malaria parasite, Plasmodium falciparum, role in health disease contin...

BACKGROUND Waldenström's macroglobulinemia (WM) is a CD20 expressing B-cell malignancy represented by the pathological diagnosis of IgM secreting lymphoplasmacytic lymphoma. Major response rates of 30% have been reported in most studies with standard dose rituximab, i.e. 4 weekly infusions at 375 mg/m(2)/week. METHODS In an effort to increase rituximab activity in WM, an extended dose schedul...

OBJECTIVES Paroxysmal nocturnal hemoglobinemia (PNH) is a rare but serious condition characterized by complement-mediated red blood cell (RBC) hemolysis and episodic thrombotic attack. It results from decay accelerating factor (CD55), and protectin (CD59), becoming attached to RBC and other cell surfaces. Absence of these protective proteins leaves such cells vulnerable to self attack at the C3...

Glycosylphosphatidylinositol-anchored proteins on the egg surface have been proposed to play a role in gamete fusion on the basis of in vitro experiments. We tested this hypothesis by asking if oocyte GPI-anchored proteins are required for fertilization in vivo. Oocyte-specific knockout mice were created using the Cre/loxP system to delete a portion of the Pig-a gene, which encodes an enzyme in...

Abstract Background and Aims Ischemia-reperfusion injury is an inevitable event associated with kidney transplantation (Tx) has a major impact on short- long-term graft survival. Proximal tubular epithelial cells are both source of complement during Tx target activation. The normal capacity to protect itself from activation through cellular expression regulatory proteins. In this study we inves...

BACKGROUND The presence of paroxysmal nocturnal hemoglobinuria clones in the setting of aplastic anemia or myelodysplastic syndrome has been shown to have prognostic and therapeutic implications. However, the status of paroxysmal nocturnal hemoglobinuria clones in various categories of myelodysplastic syndrome and in other bone marrow disorders is not well-studied. DESIGN AND METHODS By using...