Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for rats group. 20 mg/kg given CLP-Sinapic At end experiment, were collected biochemical analyzes evaluated. Results: For tissue samples; antioxidant levels decreased, oxidant increased ...

Background Sepsis-associated encephalopathy (SAS) is a neurological complication of severe systemic inflammatory episode that compromises brain function. This impairment can lead to cognitive dysfunction appears precede neurodegenerative disorders such as Alzheimer’s disease. However, the events by which inflammation causes significant damage are not yet fully established. With in mind, this st...

The use of computed tomography colonography or virtual colonography (VC) is gaining acceptance as a screening modality for colon cancer. A comprehensive understanding of VC complications is limited. We report a case of colon perforation in a patient where a colon cancer was diagnosed using VC colonography with manual insufflation. A 79-year-old patient underwent a VC after a failed screening op...

We developed two models of sepsis with different degrees of severity, sublethal and lethal sepsis, induced by cecal ligation and puncture. Lethal sepsis induced by cecal ligation and puncture (L-CLP) resulted in failure of neutrophil migration to the infection site and high mortality. Treatment of septic animals with aminoguanidine (AG), a nitric oxide (NO) synthase inhibitor, precluded the fai...

BACKGROUND Previous studies suggest that the transient receptor potential vanilloid 1 (TRPV1) channel has a role in sepsis, but it is unclear whether its effect on survival and immune response is beneficial or harmful. METHODS We studied the effects of genetic (Trpv1-knockout vs. wild-type [WT] mice) and pharmacologic disruption of TRPV1 with resiniferatoxin (an agonist) or capsazepine (an an...

Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial infection. It has been routinely simulated in animals by several techniques, including infusion of exogenous bacterial toxin (endotoxemia) or bacteria (bacteremia), as well as surgical perforation of the cecum by cecal ligation and puncture (CLP). CLP allows bacteria spillage and fecal contamination of the per...