Assay-guided fractionation led to the isolation of nine beta-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus. All isolated beta-dihydroagarofuran sesquiterpenoids were tested for their cytotoxic activity against human melanoma A375-S2 and human cervical carcinoma Hela cell lines. Among them, compounds 1-5 and 7 showed cytotoxic activity. Compound 3 exhibited promisin...

Paniculatin (1) (6α-acetoxyazadirone) and Paniculatol (2) (dihydroxycompound of 6α-acetoxyazadirone) are two naturally occurring meliacins have been isolated from the fruits and wood of chisocheton paniculatus Hiern. Chemical transformations of paniculatin and paniculatol gave 2-aminothiazolo [4,5-d] [1,2,20,21,22,23-hexahydro] paniculatin (4a), 2aminothiazolo [4,5-d] [6α,7α-dihydroxy-1,2,20,21...

A novel agarofuran sesquiterpene polyol ester, 1beta,2beta,6alpha,15beta-tetracetoxy-8 beta,9alpha-dibenzoyloxy-beta- dihydroagarofuran (celahin D) (1), two known analogues of 1,1beta-acetoxy-8beta,9alpha-dibenzoyloxy-4al pha6alpha-dihydroxy-2beta(alphamethylbutanoyloxy)-beta-++ +dihydroagarofuran (2) and beta-acetoxy-8beta,9alpha-dibenzoyloxy-6alpha-hy droxy-2beta(alpha -methylbutanoyloxy)-bet...

Celastrus paniculata, Willd, is a woody liane belongs to the family Celastraceae The plant is popularly known as “Jyothismathi” in Ayurvedic system of medicine. The bark of this plant is useful as an abortificient. The leaves and leaf sap is a good antidote to opium poisoning. In the present study, the compound was separated by using coloum chromatography method and purity of the compound was c...