Background: With the increase in life expectancy, middle aged and elderly people comprise a substantial percentage of the population worldwide. Since aging often manifests itself in the human skin, skin rejuvenation methods have gained a lot of popularity. Current medical modalities such as botulinum toxininjection, fillers, and laser therapy can provide symptomatic relief of skin aging s...

Abstract Adipose tissue mass and adiposity change throughout the lifespan. During aging, while visceral adipose (VAT) tends to increase, peripheral subcutaneous (SAT) decreases significantly. Unlike VAT, which is linked metabolic diseases, including type 2 diabetes, SAT has beneficial effects. However, molecular details behind aging-associated loss of remain unclear. Here, by comparing scRNA-se...