abstract: objective: giant cell tumor of soft parts is a rare neoplasm that mainly affects adulst and the elderly and is usually located in the extremities. here we report a child with giant cell tumor of soft tissue, which is a very rare condition in childhood. clinical presentation: a 5 year old girl presented with a 5 month history of left lower extremity pain. she had developed paraplegia b...

Stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type I diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. In addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

objective(s):this study focused on the effect of waterpipe smoke exposure toxicity on the structure of albino rat’s ventricular tissue and their recovery. materials and methods: albino rats were divided into three groups: control, flavored, and unflavored. the control group was exposed to normal air while the flavored and unflavored groups were exposed to waterpipe smoke for a period of 90 days...

allogeneic hematopoietic stem cell transplantation is used in the treatment of patients suffering from hematologic and non-hematologic disorders, but the application is limited by the identification of a suitable donor. umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell (hsc) transplantation. despite all advantages, the limited cell dose is one of the  major obstacle...

objective: development of high producing mammalian cell lines is a major bottleneck in manufacturing of recombinant therapeutic proteins. this study examines the effect of using the matrix attachment region from the human interferon beta gene in combination with promoter activation strategy with e1a 13s protein on human tissue plasminogen activator (t-pa) expression in chinese hamster ovary (ch...

background mesenchymal stem cells (mscs) are ideal candidates for treatment of diseases. amniotic membranes are an inexpensive source of mscs (am-msc) without any donor site morbidity in cell therapy. adipose tissue derived stem cells (ascs) are also suitable cells for cell therapy. there is discrepancy in cd271 expression among mscs from different sources. in this study, the characteristics of...

metastases of internal tumors to the oral cavity are unusual and in most cases involve maxilla and mandible. metastases to the gingival soft tissue are extremely rare. reporting a new clinical case of renal cell carcinoma (rcc) metastasis with an unusual site. metastatic involvement of gingival tissue with renal cell carcinoma is an extremely rare clinical event. it is usually associated with i...

background  isolation of adipose tissue mesenchymal stem cells (mscs) with current enzymatic methods has some limitations. for example, it is costly and time-consuming and results in a heterogeneous cell population that making compromise proliferation and differentiation of mscs. also, it is accompanied with the increased risk of culture contaminations because of several handling steps.in this ...

conclusions stem cell therapies in wound care may lessen the morbidities associated with wound healing. an ideal method for the effective administration of stem cells for burn patients has not yet been elucidated. further comparison of the local and systemic effects in burn patients, associated with each route of stem cell delivery, needs to be performed. results application of cells to the bur...

background: human dental stem cells have high proliferative potential for self-renewal that is important to the regenerative capacity of the tissue. objective: the aim was to isolate human dental pulp stem cells (dpsc), periodontal ligament stem cells (pdlsc) and periapical follicle stem cells (pafsc) for their potential role in tissue regeneration. materials and methods: in this experimental s...