نتایج جستجو برای: cell mediated

تعداد نتایج: 1933852  

Journal: :journal of reports in pharmaceutical sciences 0
reza khodarahmi zahra hossein-pour kamran mansouri seyyed abolghasem ghadami

the aberrant assembly of proteins into fibrillar aggregates is accused to be the primary cause of pathogenesis of neurodegenerative diseases. but the structural determinants of protein fibrils that are responsible for cell dysfunction are not yet clear. in the current study, cell culture, spectroscopic techniques as well as theoretical and structural investigations were used to determine the ab...

Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and Methods: We chose the appropriate time and concentration of recombinant human Sonic hedgehog (Shh) stimulation by cell viability. The proportion of cel...

Journal: :journal of pharmaceutical and health sciences 0
mojtaba falahati department of nanotechnology, faculty of advance science and technology, pharmaceutical sciences branch, islamic azad university (iaups), tehran, iran

nowadays, growing interest in the application of nanotechnology in biomedical and biotechnological fields has opened a new avenue to explore the nanoparticles-biological system interaction. indeed, a clear gap is still in the cytotoxic effect of nps on the biological systems. for this purpose, the interaction of the silica oxide nanoparticles (sio2-np) with pc12 cell line, as a model of nervous...

Journal: :iranian journal of applied animal science 2013
r.j. patil j.s. tyagi m. sirajudeen r. singh r.p. moudgal

the aim of the present work was to determine whether the administration of melatonin or l­-tryptophan (a precursor of melatonin) affects the immune responses and performance of broilers during induced exposure to aflatoxins in feed. the study was conducted from 0-6 weeks comprising six dietary treatments in triplicate with10 chickens in each replicate. the diets were formulated to supply 23% cr...

Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated.   Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...

Farshad Forooghi, Hajar Nasiri, Hassan Ehteram, Mehdi Azad, Mousa Vatanmakan, Naser Mobarra,

Background: Stem Cell differentiation is a process composed of vast variety of factors which are controlled by a network of certain mechanisms. This study aims to determine the possible role of DNA methylation, a potent regulator of VHL, ECAD and RUNX3 genes during Erythroid differentiation driven by miR-451. Materials and Methods: To determine the methylation status of promoters and the e...

Journal: :cell journal 0
sedigheh ganji-harsini mozafar khazaei zahra rashidi ali ghanbari

objective: thymoquinone (tq), as the main component of nigella sativa plant, shows anticancer properties. this study was aimed to evaluate the combined effect of tq and tamoxifen (tam) on viability and apoptosis of human breast cancer cell lines. materials and methods: in this experimental study, estrogen positive mcf-7 and estrogen negative mda-mb-231 human breast cancer cell lines were induce...

Abdolhoseein Dalimi Ahmad Daryani, Ahmad Zavaran Hosseini Hajar Ziaei Mehdi Sharif Mohammad Hossein Dehghan

Background: Toxoplasma gondii is an obligate intracellular parasite that infects all mammalian cells. Several antigens such as excreted/secreted antigens have been identified as a potential vaccine candidate. Objective: To determine how excreted/secreted antigens from peritoneal exudates of infected mice (mESA) stimulate cell-mediated immune responses and induce protective immunity against toxo...

امیر زرگر, علی اکبر , خسروی, فریده , رفیعی نژاد, علی , لاریجانی, باقر , نیکنام, محمد حسین ,

Background: Type 1A Diabetes Mellitus (T1DM) is a chronic and progressive auto- immune disorder resulting from immune mediated destruction of Langerhans islet beta cells. The etiology of T1DM like the other autoimmune diseases is unknown and many factors are involved, Both humoral and cell-mediated immunity have a critical role in T1DM pathogenesis. The cytokines, the immunomodulatory peptides,...

Journal: :Advanced Materials 2022

Cell Adhesion In article number 2110340, Ramasamy Paulmurugan, Young Keun Kim, Heemin Kang, and co-workers report template-mediated in situ tuning of nanoligand size spacing. They demonstrate that submolecular ligand spacing magnetic anchoring facilitate adhesion-structure assembly-mediated pro-healing polarization host macrophages. Increasing the significantly suppresses macrophage adhesion wh...

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