After kidney transplantation (KT), donor-specific hyporesponsiveness (DSH) of recipient T cells develops over time. Recently, apoptosis was identified as a possible underlying mechanism. In this study, both transcriptomic profiles and complete V(D)J variable regions TR transcripts from individual alloreactive transplant recipients were determined with single-cell RNA sequencing. Alloreactive by...

Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.

Background: We performed a retrospective analysis to determine the incidence of neurotrophic tropomyosin-receptor kinase (NTRK) fusion in non-small cell lung cancer (NSCLC).

Immunological synapse (IS) is a high-specialized connection between T-lymphocyte and an antigen-presenting cell (APC), consisting of cluster T-cell receptors (TCR) surrounded by ring adhesion molecules. It has now been shown that formation immune synapses active dynamic mechanism allows T cells to discriminate potential antigenic ligands. At the first stage receptor ligands are involved in exte...

Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...

Each cell has receptors on the surface that specifically bind to solutes (ligands) produced during tissue damage or infection. This review aimed describe role of PRR in human body's defense system. The binding ligand its receptor results activation intracellular signaling pathways and activation. B T lymphocytes adaptive immune system have developed (that is, T-cell receptor, TCR, B-cell BCR) a...

Human noroviruses (HuNoVs) are a leading cause of gastroenteritis resulting in up to 200,000 deaths each year. The receptor and cell tropism HuNoV immunocompetent humans unclear.

background: th1 cells preferentially express cxcr3, ccr5 and ccr6, while ccr3 and ccr4 are predominantly expressed by th2 cell subsets. multiple sclerosis (ms) is a th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. objective: this study was performed to measure c...