Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.

Predicting whether T cell receptors bind to specific peptides is a challenging problem because most binding examples in the training data involve only few peptides. A new approach uses meta-learning improve predictions for which no or little exists.

A particular characteristic of the neonatal hippocampus is the presence of spontaneous network-driven oscillatory events, the so-called giant depolarizing potentials (GDPs). GDPs depend on the interplay between GABA and glutamate. Early in development, GABA, acting on GABAA receptors, depolarizes neuronal membranes via a Cl- efflux. Glutamate, via AMPA receptors, generates a positive feedback n...

objective: vascular endothelial growth factor (vegf) and vegf receptors (vegfrs) play important roles in angiogenesis of different developmental mechanisms such as wound healing, embryogenesis and diseases, including different types of cancer. vegfr2 is associated with cell proliferation, migration, and vascular permeability of endothelial cells. blocking vegf and its receptors is suggested as ...

The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in part is associated with gelatinase from neutrophils. This shows high degree of sequence similarity the deduced sequences rat α -microglobulin-related mouse 24p3. Based on its typical lipocalin fold, which consists an eight-stranded, anti-parallel, symmetrical β-barrel fold structure it initially thought L...

Hidradenitis suppurativa (HS) is a chronic systemic and cutaneous inflammatory disease driven by multitude of immune cells. Recent studies have demonstrated that IL17A/IL17F isoform signal blocking psoriasis (PsO) drugs can effectively treat HS, suggesting Type 17 T-cells (T17 cells) play critical role in HS lesion development. We sought to define compare the single-cell transcriptomes T17 cell...

objective (s):hyperglycemia is widely recognized as the underlying cause for some debilitating conditions in diabetic patients. the role of cannabinoid cb1 and vanilloid trpv1 receptors and their endogenous agonists, endovanilloids, in diabetic neuropathy is shown in many studies. here we have used pc12 cell line to investigate the possible influence of glucose concentration in culture medium o...

bisphenol-a (bpa) is an industrial xenoestrogen used widely in our living environment. recently, several studies suggested that bpa has destructive effects on dna and chromosomes in normal body cells via estrogen receptors (er). therefore, bpa could be considered as an important mediator in many diseases such as cancer. however, there are still many controversial issues which need clarification...

We propose a computational investigation on the interaction mechanisms between SARS-CoV-2 spike protein and possible human cell receptors. In particular, we make use of our newly developed numerical method able to determine efficiently effectively relationship complementarity portions surfaces. This innovative general procedure, based representation molecular isoelectronic density surface in te...