The directly compressible floating-bioadhesive tablets of tramadol were formulated using varying amounts Carbopol 971P (CP) and hydroxy-propylmethyl cellulose (HPMC), along with other requisite excipients. In vitro drug release profile, floatational characteristics and ex vivo bioadhesive strength using texture analyzer were determined, and systematically optimized using a 3(2) central composit...

Production of mycophenolic acid (MPA) by submerged fermentation using the microfungus Penicillium brevicompactum MTCC 8010 is reported here. Screening experiments were used to identify: the suitable media composition; the optimal initial pH; and the optimal incubation temperature to maximize the production of MPA in batch cultures. The initial concentrations of the selected sources of carbon (g...

Background: Application of potassium ferrate is a chemical oxidation approach used for water and wastewater treatment. The aim of this study is to apply central composite design (CCD) and response surface methodology (RSM) to optimize potassium ferrate consumption in the treatment of wastewater from carpet industries. Methods: Samples in this experimental study were collected from wastewater...

Physical or chemical processes can enrich surface functional groups of activated carbon. EDTA grafting was applied to the carbon using a treatment in this study. In way, while there no significant change area carbon, Golden Yellow (GY) removal performance increased. The changes caused by on have been revealed various methods. Environmental conditions affecting adsorption process were statistica...

Pectin from passion fruit peels was extracted using citric acid extraction. The effects of citric acid concentration from 0.05 to 0.21 % (wt/wt), extraction time from 30 to 120 minutes and extraction temperatures from 35 to 85 ̊C on pectin yield and the degree of esterification (DE) were investigated. Using the central composite design (CCD), the optimized pectin yield was 6.44 % and degree of ...

A quadratic central composite design (CCD) in response surface methodology was applied to explicate the combinational concentration of effectors that influence fermentative cellulase production by Brevibacillus parabrevis. It was examine that 10% inoculums ((7X10/ml)) concentration and 37C temperature was optimum for cellulase production after 24 h of fermentation. Concentration of effectors (g...

A novel metal–organic framework (MOF), with the formula [Cu(II)L]n (L=4, 4′-diamino diphenyl sulfone), has been synthesized conventionally andhydrothermally methods and characterized by FT-IR, PXRD, EDX, and SEMtechniques. The results MOFs were applied for photodegradation of MethyleneBlue (MB). The influence of affecting variables, such as initial MB dyeconcentrat...

This paper presents a comparison of two different techniques of Soft Computing (SC), in union with a novel approach of a hybrid model with Central Composite Design (CCD) with capacity of performing a rule reduction, without loss of reliability, and also performs a reduction of the computational time spent in prediction. Results obtained with this method show better performance thought generatin...