نتایج جستجو برای: cerebral cortex methamphetamine neurotoxicity

تعداد نتایج: 292796  

Journal: :Pharmacological reports : PR 2013
Matthew J Robson Michael J Seminerio Christopher R McCurdy Andrew Coop Rae R Matsumoto

BACKGROUND Methamphetamine (METH) causes hyperthermia and dopaminergic neurotoxicity in the rodent striatum. METH interacts with σ receptors and σ receptor antagonists normally mitigate METH-induced hyperthermia and dopaminergic neurotoxicity. The present study was undertaken because in two experiments, pretreatment with σ receptor antagonists failed to attenuate METH-induced hyperthermia in mi...

2014
Joseph O’Neill Marc C. Tobias Matthew Hudkins Edythe D. London

BACKGROUND The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to abstinence-induced downregulation of the glutamatergic systems in the brain. This study fur...

Journal: :Stroke 2012
Ayman ElAli Andrés Urrutia Ana Rubio-Araiz Macarena Hernandez-Jimenez Maria I Colado Thorsten R Doeppner Dirk M Hermann

BACKGROUND AND PURPOSE Methamphetamine is a powerful addictive, which has been associated with ischemic stroke and brain hemorrhage in humans. Whether and how methamphetamine influences the expression of tight junctions and adenosine triphosphate-binding cassette transporters, which have previously been shown to be regulated by apolipoprotein-E (ApoE) under conditions of brain ischemia, was unk...

2013
Michela Ferrucci Filippo S Giorgi Alessia Bartalucci Carla L Busceti Francesco Fornai

The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focus...

2016
Ali Gurel

Methamphetamine (MA) may cause hepatotoxicity, rhabdomyolysis, acute kidney injury, and neurotoxicity separately or together. We report a patient admitted with muscle weakness, pain, and oliguria 1 week after MA use; requiring repeated hemodialysis (HD). Multisystem toxicity may develop as a result of MA use and appropriate treatment may be life saving.

Journal: :Annals of the New York Academy of Sciences 2008
Joana Gonçalves Tânia Martins Raquel Ferreira Nuno Milhazes Fernanda Borges Carlos Fontes Ribeiro João O Malva Tice R Macedo Ana P Silva

The mechanisms by which methamphetamine (METH) causes neurotoxicity are not well understood. Recent studies have suggested that METH-induced neuropathology may result from a multicellular response in which glial cells play a prominent role, and so it is plausible to suggest that cytokines may participate in the toxic effects of METH. Therefore, in the present work we evaluated the effect of an ...

Journal: :The Journal of pharmacology and experimental therapeutics 2013
Danielle M Friend Jong H Son Kristen A Keefe Ashley N Fricks-Gleason

Nitric oxide is implicated in methamphetamine (METH)-induced neurotoxicity; however, the source of the nitric oxide has not been identified. Previous work has also revealed that animals with partial dopamine loss induced by a neurotoxic regimen of methamphetamine fail to exhibit further decreases in striatal dopamine when re-exposed to methamphetamine 7-30 days later. The current study examined...

ژورنال: Anatomical Sciences Journal 2004
Haghir, Hosein, Mehr Aein, Parviz,

Purpose: This study sought to determine sex differences in surface anatomical parameters (thickness and surface areas) of human cerebral cortex in different lobes of the left hemisphere in normal right-handed subjects and right-handed subjects suffering from Alzheimer and Parkinson's diseases. Materials and Methods: This cross-sectional descriptive study was performed on 72 normal human brains...

2014
Soghra Mehri Mehran Shahi Bibi Marjan Razavi Faezeh Vahdati Hassani Hossein Hosseinzadeh

OBJECTIVES Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the current study was the evaluation of effects of thymoquinone, the main constituent of volatile oil from Nigella sativa seeds in ACR-induced neuroto...

2017
M. Ram Kumar Rajarami Reddy

This study was planned to determine the influence of age on arsenic (As; 10mg/kg body weight given through oral gavage) induced mitochondrial oxidative stress in three different age groups of rats; young (postnatal day [PND] 21), adult (3 months) and aged (18 months) at seven days post-acute exposure. Further, we also evaluated the therapeutic efficacy of essential metal Zinc (Zn; 0.02% through...

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