Although PCR analysis is a sensitive test for detection of human papillomavirus (HPV) in the cervix, the proportion of cases of cervical dysplasia missed, or the false-negative rate, has been unknown. We determined the accuracy of PCR analysis for HPV DNA as a predictor of HPV-related cervical lesions in a cross-sectional study of sexually active women, aged 18 to 50 years, from the University ...

BACKGROUND Human papillomavirus (HPV) has been recognized as a necessary, but not sufficient, cause of cervical cancer. AIM In this study, we investigated the prevalence of HPV and the genotype distribution in women from Natal, North-East Brazil, with normal cytology and with cervical lesions of different degrees. SUBJECTS AND METHODS Included in this study were 110 women with a normal cyto...

OBJECTIVES To evaluate the correlation of AgNOR count and colposcopy in cases of suspicious cervix. METHODS A hundred women presenting in OPD with complaints of postcoital bleeding, discharge per vaginum, pain in the lower abdomen, or intermenstrual bleeding were subjected to colposcopy. After colposcopy, a cervical biopsy was done. Routine paraffin sectioning was done for these biopsy specim...

In spite of preventive measures such as Papanicolaou cervical cytological analysis and, more recently, vaccination against HPV infection, cancer of the uterine cervix continues to be one of the most frequent causes of mortality among women worldwide, particularly in developing countries. In this prospective study, sixty patients with inflammatory Pap smears had a colposcopy with directed biopsi...

The expression of simple mucin-type carbohydrate antigens, Tn and sialyl-Tn antigens, was evaluated by immunohistochemical staining with monoclonal antibodies in normal squamous epithelium, dysplasia, carci noma in situ, and invasive squamous cell carcinoma of the uterine cervix. The expression of the Tn antigen detected by HB-Tnl and Bl.l was found in 17 (20%) and 19 (23%) of the 83 invasive c...

The expression of simple mucin-type carbohydrate antigens, Tn and sialyl-Tn antigens, was evaluated by immunohistochemical staining with monoclonal antibodies in normal squamous epithelium, dysplasia, carcinoma in situ, and invasive squamous cell carcinoma of the uterine cervix. The expression of the Tn antigen detected by HB-Tn1 and B1.1 was found in 17 (20%) and 19 (23%) of the 83 invasive ca...