Peripheral blood monocyte subpopulations have been reported and can give rise to diverse, differentiated phenotypes. A subpopulation(s) of human monocytes can proliferate in vitro in response to macrophage-colony stimulating factor (M-CSF; or CSF-1). This population, termed the proliferative monocyte (PM), is presumably less mature than other monocytes; however, it has not been defined further....

The BCR/ABL tyrosine kinase inhibitor imatinib mesylate is highly effective in the treatment of chronic myelogenous leukemia (CML) but fails to eliminate all leukemia cells. Residual leukemia stem and progenitor cells persist in imatinib-responsive patients and may be a potential source of relapse. Previous studies indicate that imatinib preferentially targets dividing cells, and nondividing pr...

Dendritic cells (DCs) are able in tissue culture to phagocytose and present antigens derived from infected, malignant, and allogeneic cells. Here we show directly that DCs in situ take up these types of cells after fluorescent labeling with carboxyfluorescein succinimidyl ester (CFSE) and injection into mice. The injected cells include syngeneic splenocytes and tumor cell lines, induced to unde...

Immunity induced by the 19-kDa fragment of merozoite surface protein 1 is dependent on CD4+ Th cells. However, we found that adoptively transferred CFSE-labeled Th cells specific for an epitope on Plasmodium yoelii 19-kDa fragment of merozoite surface protein 1 (peptide (p)24), but not OVA-specific T cells, were deleted as a result of P. yoelii infection. As a result of infection, spleen cells ...

We carry out computational inverse problem investigations to determine the importance of allowing for unequal label allocation to daughter cells during mitosis. Parameter estimations are performed using previously developed label-structured partial differential equation models that utilize cytons to account for variability in times between cell divisions as well as times until cell death. These...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 206 No. 2 307–328 www.jcb.org/cgi/doi/10.1083/jcb.201403127 JCB 307 E. Frittoli and A. Palamidessi contributed equally to this paper. P.P. Di Fiore and G. Scita contributed equally to this paper. Correspondence to Pier Paolo Di Fiore: [email protected]; or Giorgio Scita: [email protected] Abbreviations used in this paper: CF...

Introduction Atomic Structures and Properties Electronic configurations Radii of atoms and ions Ionisation enthalpies Oxidation states Compound formation in maximum oxidation states Stability of compounds in aqueous solution Magnetic properties Coloured ion formation Alloy formation Interstitial compound formation Coordination Compounds Types of ligands Homleptic and heteroleptic complexes Coor...