Skin hyperpigmentation is a biological process that results in an excess production of melanin. Tyrosinase inhibition effective approach to this condition, although inhibitors reported the literature lack clinical efficacy or show toxic effects. Chalcone derivatives are well known tyrosinase but insoluble aqueous phase limiting its use final product formulations. The aim study develop new chalc...

Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in research to develop sunscreen agent has been increasing. Chalcone promising compound be developed as its chromophore absorbs UV region. Therefore, present work, we synthesized eight chalcone derivatives through Claisen–Schmidt condensation at room temperature. The evaluation of optical properties each region ...

Stigma is a crucial structure of female reproductive organ in plants. Stigma color is usually regarded as an important trait in variety identification in some species, but the molecular mechanism of stigma color formation remains elusive. Here, we characterized a tomato mutant, yellow stigma (ys), that shows yellow rather than typical green color in the stigma. Analysis of pigment contents reve...

In this study, a facile and versatile procedure for the synthesis of chalcone derivate that functionalized (E,Z)-2-(4-aminobenzylidene)acenaphthylen-1(2H)-one, 4 was synthesized also characterized by using FT-IR, NMR MS. A new HPLC method separation its diastereomers developed chiral column contains amylose tris(3,5-dimethylphenylcarbamate) as selector since it is effective, reproducible can be...

Four series of novel bis-chalcone compounds with excellent performances have been synthesized and examined for the first time as photoinitiators in combination an amine iodonium salt FRP acrylates CP EPOX.

Bacterial contamination in blood product was still a problem Indonesia. Various studies to improve the safety of by inhibiting bacterial growth developed. Chalcone, is one natural compounds that has ability inhibit growth, so it can be possible use compound for anti-bacterial future. This study aim evaluate activity novel synthesis chalcone (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one agains...

Flavonoids are secondary metabolites that are present at high levels in the Polugonum minus. In recent years, flavonoids have attracted the interest of researchers because of their antioxidant properties .Flavonoids are synthesised via the condensation of 4 coumaryl-CoA and 3 malonyl-CoA by the action of Chalcone synthase. A cDNA encoding a chalcone synthase was isolated from the leaves of Poly...

Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated its inhibitory effects on endotoxin-stimulated production of reactive oxygen spec...