TREATMENT OF LEAD TOXICITY with chelation was first reported with EDTA in the early 1950s. Apparent success in reducing metastatic calcium deposits led Clarke et al in 1956 to treat angina patients with EDTA, and others to use chelation for various forms of atherosclerotic disease. Chelation therapy evolved to constitute infusions of vitamins and disodium EDTA, a drug that binds divalent and so...

OBJECTIVE This prospective pilot study aimed at evaluating the effects of therapy with antioxidant compounds (Cellfood, and other antioxidants) on patients affected by neurodegenerative diseases (ND), who displayed toxic metal burden and were subjected to chelation treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA or EDTA). METHODS Two groups of su...

The effects of dietary polyphenols on human health have mainly been discussed in the context of preventing degenerative diseases, particularly cardiovascular diseases and cancer. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanism of action of polyphenols extends beyond the modulation of oxidative stress, as they are poorly absorbed fro...

plants with hypoglycemic properties are important in the treatment of diabetes. one of the mechanisms in reducing blood glucose is preventing the digestive absorption of glucose. the aim of this study was to evaluate the antioxidant properties of some traditional medicinal plants collected from different regions of iran and their effects on glucose diffusion decrease. the amounts of phenolic co...

Abstract The present study aimed to determine the prevalence of hypothyroidism, hypoparathyroidism and the frequency of regular chelation therapy in patients with thalassemia major in Iran. Searching process was performed by two independent  researchers using valid keywords in the national and international database, including: Magiran, Iranmedex, SID, Medlib, Scopus, PubMed, Science ...

Polyphenols, a class of natural products, have been shown to exhibit cancer protective properties. Proprotein convertases form a family of mammalian subtilisin-like serine endoproteases. Increased expression of these enzymes has been associated with numerous pathologies including cancer. It has been suggested that the cancer protective effect of polyphenols might be related to their proprotein ...

PURPOSE To determine whether low-normal body lead burden (BLB) accelerates progressive renal insufficiency in nondiabetic patients with chronic kidney diseases (CKD). METHODS One hundred eight CKD patients (serum creatinine between 1.5 and 2.9 mg/dL) with low-normal BLB (<80 microg) and no lead exposure history were observed for 24 months. Following the observation, 32 patients with low-norma...

Background: Cadmium (Cd) is an extremely toxic metal and environmental exposure to Cd has been particularly problematic in the world. Oral exposure to Cd may result in adverse effects on a number of tissues, the immune system, and the cardiovascular system. Compounds containing Cd are also carcinogenic. The presence of Cd in drinking water resources in the southeastern region of Rafsanjan plain...