A new field of science, chemical biology/ chemical genetics/ chemical genomics (cb/cg/cg) has emerged since the late 1990's, especially in the United States. The NIH Roadmap agenda, Molecular Libraries Screening Center Network (MLSCN), became a drive force to push cb/cg/cg forward. Cb/cg/cg studies consist of three methodologies, chemical libraries with small molecules, high-throughput screenin...

the aim of this study was to investigate the allelopathic effects of eucalyptus camaldulensis on germination and early seedling growth of festuca arundinacea under laboratory condition in order to determine the effect of pretreatments on decreasing the destructive effects of allelopathic compounds. the chemical stimulators used in this study included 3 levels of gibberellic acid, 3 levels of sa...

A novel technique to annotate, query, and analyze chemical compounds has been developed and is illustrated by using the inhibitor data on HIV protease-inhibitor complexes. In this method, all chemical compounds are annotated in terms of standard chemical structural fragments. These standard fragments are defined by using criteria, such as chemical classification; structural, chemical, or functi...

The review describes chemical transformations of multifunctional compounds (amino acids and peptides, amino alcohols, amino thiols, hydroxy acids, oxo acids, oxo alcohols, compounds containing simultaneously three or more different groups etc.) by using step-wise or one-step modification or protection of functional groups. Some chemical aspects of mixed derivatization performed for improving th...

the aim of this study was to determine and scrutiny about chemical compounds and microbial load changes of broiler chicks’ diet due to gamma irradiation processing. there were 12 broiler chicks’ diets weighting one kg that including 4 packs from starter period, 4 packs from grower period and 4 packs from finisher period. feeds were irradiated in four doses including 0, 6.7, 7.7 and 8.7 kilogray...

Drug design is the approach of finding drugs by design using computational tools. When designing a new drug, the structure of the drug molecule can be modeled by classification of potential chemical compounds. Kernel Methods have been successfully used in classifying chemical compounds, within which the most popular one is Support Vector Machine (SVM). In order to classify the characteristics o...

BACKGROUND In traditional medicine, there has been a great deal of research on the effects exhibited by medicinal materials. To study the effects, resources that can systematically describe the chemical compounds in medicinal materials are necessary. In recent years, numerous databases on medicinal materials and constituent compounds have been constructed. However, because these databases provi...

in theoretical chemistry, molecular structure descriptors are used to compute properties of chemical compounds. among them wiener, szeged and detour indices play significant roles in anticipating chemical phenomena. in the present paper, we study these topological indices with respect to their difference number.