Background and Aims : Proprotein convertase subtilin/kexin type 9 (PCSK9) is a protease that gained importance in cardiovascular biology due to its regulatory action on the low-density-lipoprotein receptor (LDLR). However, PCSK9 can also act independent of LDLR cause vascular pathologies. We hypothesized affects expression chemokine-receptors CXCR4, CCR8, CCR5 CCR2 inflammatory cytokines, all m...

Viruses have evolved a myriad of evasion strategies focused on undermining chemokine-mediated immune surveillance, exemplified by the mouse gamma-herpesvirus 68 M3 decoy receptor. Crystal structures of M3 in complex with C chemokine ligand 1/lymphotactin and CC chemokine ligand 2/monocyte chemoattractant protein 1 reveal that invariant chemokine features associated with G protein-coupled recept...

Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effec...

The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in the diseased kidneys. Chemokine/chemokine receptor systems may be e...

Expression of chemokine receptors by tumors, specifically CCR4 on cutaneous T cell lymphomas, is often associated with a poor disease outcome. To test the hypothesis that chemokine receptor-expressing tumors can be successfully controlled by delivering toxins through their chemokine receptors, we have generated fusion proteins designated chemotoxins: chemokines fused with toxic moieties that ar...

Although aplastic anemia and myelodysplasia have been extensively investigated, little is known about their circulating cytokine patterns. We compared plasma soluble cytokines in 33 aplastic anemia, 57 myelodysplasia patients, and 48 healthy controls. High levels of thrombopoietin and granulocyte colony-stimulating factor, with low levels of CD40 ligand, chemokine (C-X-C motif) ligand 5, chemok...

Chemokines and their receptors represent a potential target for immunotherapy in chronic inflammation. They comprise large family of cytokines with chemotactic activity, cognate are expressed on all cells the body. This network dictates leukocyte recruitment activation, angiogenesis, cell proliferation maturation. Dysregulation chemokine receptor expression as well function participates many pa...