Discriminating ability (selectivity) of chemoreceptor neuron is compared with that of its receptor proteins. The process of neuronal triggering is expected to be cooperative and threshold-type in a sense that the neuron can fire if and only if the number of its receptor proteins, which are bound with odor molecules, is above a definite threshold. Both deterministic and stochastic pictures are c...

Feeding state and food availability can dramatically alter an animals' sensory response to chemicals in its environment. Dynamic changes in the expression of chemoreceptor genes may underlie some of these food and state-dependent changes in chemosensory behavior, but the mechanisms underlying these expression changes are unknown. Here, we identified a KIN-29 (SIK)-dependent chemoreceptor, srh-2...

Peripheral chemoreceptor activity/sensitivity is enhanced in chronic heart failure (HF), and sensitivity is linked to greater mortality. This study aimed to determine the role of the peripheral chemoreceptor in cardiovascular control at rest and during exercise in HF patients and controls. Clinically stable HF patients (n = 11; ejection fraction: 39 ± 5%) and risk-matched controls (n = 10; ejec...

44 Ventral respiratory column (VRC) circuits that modulate breathing in response to changes in 45 central chemoreceptor drive are incompletely understood. We employed multi-electrode arrays 46 and spike train correlation methods to test predictions of the hypothesis that pre-Bötzinger 47 complex (pre-BötC) and retrotrapezoid nucleus/parafacial (RTN-pF) circuits cooperate in 48 chemoreceptor-evo...

Carotid chemoreceptor type 1 cells release dopamine, which inhibits carotid chemoreceptor activity via dopamine D2 autoreceptors on type 1 cells. Postnatal changes in dopaminergic modulation may be involved in postnatal chemoreceptor development. The present study explores dopaminergic modulation of the intracellular calcium ([Ca(2+)](i)) response to hypoxia in type 1 cells from 1, 3, and 11- t...

Ventrolateral respiratory column (VRC) circuits that modulate breathing in response to changes in central chemoreceptor drive are incompletely understood. We employed multielectrode arrays and spike train correlation methods to test predictions of the hypothesis that pre-Bötzinger complex (pre-BötC) and retrotrapezoid nucleus/parafacial (RTN-pF) circuits cooperate in chemoreceptor-evoked tuning...

Pseudomonas sp. strain ADP utilizes the human-made s-triazine herbicide atrazine as the sole nitrogen source. The results reported here demonstrate that atrazine and the atrazine degradation intermediates N-isopropylammelide and cyanuric acid are chemoattractants for strain ADP. In addition, the nonmetabolized s-triazine ametryn was also an attractant. The chemotactic response to these s-triazi...

Dinitrophenol (2,4 dinitrophenol; DNP) was early identified as a potent stimulant of the carotid body (CB; Shen and Hauss, 1939). DNP acts directly upon chemoreceptor cells promoting an increase in the intracellular calcium concentration and the release of catecholamine (CA); both responses are strongly dependent on the presence of Ca+and Na+ in the extracellular media (Obeso et ai., 1989; Roch...