Since the introduction of chemotherapy more than 50 years ago, the prognosis of childhood cancer has improved dramatically, with overall 5-year survival rates approaching 80%. Despite these advances, several childhood cancers still have unacceptably low cure rates, and even when treatment is successful, the acute and long-term morbidity of current therapy can be substantial. Over the past decad...

Previously, we found that excess weight already in childhood has positive associations with endometrial cancer; however, associations with changes in body mass index (BMI) during childhood are not well understood. Therefore, we examined whether growth in childhood BMI is associated with endometrial cancer and its sub-types. A cohort of 155,505 girls from the Copenhagen School Health Records Reg...

While all childhood cancers are rare, tumors that particularly infrequent or underrepresented within pediatrics studied under the umbrella of Children’s Oncology Group Rare Tumor committee, divided into Retinoblastoma and Infrequent subcommittees. The subcommittee has traditionally included an emphasis on globally rare such as adrenocortical carcinoma, nasopharyngeal those in young children, de...

OBJECTIVE Evidence suggests that the in utero environment may contribute to subsequent development of cancers in childhood and adulthood. Raised levels of estrogen during pregnancy may be the primary in utero etiologic factor. Mothers of twins have higher estrogen levels during pregnancy than mothers of singletons, therefore, assessment of cancer risk in twins may be informative. METHOD We co...

A substantial proportion of childhood cancers are attributable to an underlying genetic syndrome or inherited susceptibility. Recognition of affected children allows for appropriate cancer risk assessment, genetic counseling, and testing. Identification of individuals who are at increased risk to develop cancers during childhood can guide cancer surveillance and clinical management, which may i...