Cover (and back side), Alexa488-APEC staining (green) of the adenosine A 2A receptor in living Chinese hamster ovary cell transiently transfected with pcDNA3 A 2A R as well as pAS β-arrestin2-RFP (red).

Introduction: Genital system is important herd in animal's creation. It is necessary for animal reproduction. Mammal has two sex in genital system such as male and female in separated animals. Animal reproduction destroyed by disorder of genital system. In this case, animals cannot produce an animal similar to them. Finally it cause overthrow a species of animals. Methods: Histomorpholog...

Vinca alkaloids are important chemotherapeutic agents, and their pharmacokinetic properties display significant interindividual variations, possibly due to CYP3A4-mediated metabolism. We have evaluated the relevance of this metabolism for the chemotherapeutic and the toxicological properties of these drugs. Analysis was performed using Chinese hamster ovary cell lines that expressed either CYP2...

Solid neoplasms may contain deficient or poorly functional vascular beds, a property that leads to the formation of hypoxic tumor cells, which form a therapeutically resistant cell population within the tumor that is difficult to eradicate by ionizing irradiation and most existing chemotherapeutic agents. As an approach to the therapeutic attack of hypoxic cells, we have measured the cytotoxici...

Three mammalian cell lines were examined for their ability to metabolize the regulatory oxysterol, 25-hydroxycholesterol, and derepress 3-hydroxy-3-methylglutaryl CoA reductase. In mouse L cell fibroblasts reductase activity was restored with the concomitant metabolism of 25-hydroxycholesterol via side-chain hydroxylation and scission of the C20-C22 bond. Chinese hamster lung cells did not appe...