This work describes the development of spray dried polymer coated liposomes composed of soy phosphatidylcholine (SPC) and phospholipid dimyristoyl phosphatidylglycerol (DMPG) coated with alginate, chitosan or trimethyl chitosan (TMC), that are able to penetrate through the nasal mucosa and offer enhanced penetration over uncoated liposomes when delivered as a dry powder. All the liposome formul...

Due to its bioactivity, hydroxyapatite (HAp) is one of the most perspective materials for controlled drug delivery. Biodegradable polymers like chitosan and sodium alginate are used as coating materials for ceramic scaffolds. In this work the application of HAp/sodium alginate or chitosan composite materials which provide controlled lidocaine release is discussed. The polymers and lidocaine hyd...

The present paper describes development of a polysaccharide based compression coated tablets of secnidazole for colon delivery. Core tablet containing secnidazole was compression coated with various proportions of guar gum, xanthan gum and chitosan, either alone or in combinations. Drug release studies were performed in simulated gastric fluid (SGF) for 2 h followed by simulated intestinal flui...

BACKGROUND Cytosine-phosphate-guanine (CpG) oligodeoxynucleotides activate Toll-like receptor 9, leading to induction of proinflammatory cytokines, which play an important role in induction and maintenance of innate and adaptive immune responses. Previously, we have used boron nitride nanospheres (BNNS) as a carrier for delivery of unmodified CpG oligodeoxynucleotides to activate Toll-like rece...

The aim of the present study was to develop and characterize coated chitosan-alginate beads containing cefaclor as a controlled release delivery system. Coated cefaclor beads were prepared by solvent evaporation techniques. Beads were found to be intact and spherical in shape. Their size range was 1.05 to 2.06. The loading efficiency showed maximum value when the concentration of cefaclor, chit...

In this paper, different formulation types of microparticulate systems such as beads, microbeads, microspheres and microsponges using to special attention chitosan, alginate and eudragit RS 100 are reviewed. Chitosan and alginates are natural, anionic or cationic, biocompatible, biodegredable and non-toxic polymers. They have excellent potential for pharmaceutical and biopharmaceutical applicat...

BACKGROUND Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal delivery of exendin-4. METHODS AND RESULTS Nanoparticles were prepared using a modified water-oil...

Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core...

Bone-like apatite coating of polymeric substrates by means of biomimetic process is a possible way to enhance the bone bonding ability of the materials. The created apatite layer is believed to have an ability to provide a favorable environment for osteoblasts or osteoprogenitor cells. The purpose of this study is to obtain bone-like apatite layer onto chitosan fiber mesh tissue engineering sca...

In this work, the effect of chitosan and CaCO3 coating on polyurethane (PU) foam mechanical thermal properties was studied. PU-foams were soaked in a mixture chitosan- calcium carbonate solution at different concentrations, i.e., 0.1–0.4%. The molecular behaviors due to incorporation chitosan/CaCO3 into PU-foam matrix investigated by Fourier-Transform Infrared (FTIR) spectroscopy. Field Emissio...