Upon binding to the poliovirus receptor (PVR), the poliovirus 160S particles undergo a conformational transition to generate 135S particles, which are believed to be intermediates in the virus entry process. The 135S particles interact with host cell membranes through exposure of the N termini of VP1 and the myristylated VP4 protein, and successful cytoplasmic delivery of the genomic RNA requir...

Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patientschr('39') health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-...

Cholesterol, in 0.1 gram amounts, melted in a compact mass and inserted into the subcutaneous tissues of the back of the guinea pig, is slowly removed, as determined by chemical analyses. The rate of removal is probably greatly dependent upon the physical state of the cholesterol. The quantitative estimation of cholesterol by the method previously described can not be shortened and simplified b...

1. When rat-liver mitochondria were incubated with [4-(14)C]cholesterol in the presence of a soluble supernatant fraction, various steroids more polar than cholesterol were formed. These included 3beta-hydroxycholest-5-en-26-oic acid, 3beta-hydroxychol-5-enoic acid, lithocholic acid, chenodeoxycholic acid and alpha- and beta-muricholic acids. 2. All the radioactive C(24) bile acids recovered we...

Probiotics mainly reside in host intestinal tract, where they interact with bile salts and ingested cholesterol. This paper reviews the recent progresses of probiotics on the following issues, i.e. bile salts effect on membrane composition; probiotic tolerance and modification of bile salts; the mechanism of probiotic removal of host cholesterol; and the roles that bile salt hydrolase plays. © ...

Cholesterol granuloma is a pathological lesion affecting the mastoid air cells due to partial obstruction of its aireation. It is commonly unilateral. It is usually associated with glue ear with intact ossicles. Histologically, it is characterized by the presence of large pointed crystals and giant cells. Its treatment is either conservative steroid therapy or surgical removal of the granuloma ...

A 59-year-old male presented with a large cholesterol granuloma arising from the frontal sinus manifesting as a large, fluctuated, soft mass in his brow, compressing left eye. Skull radiography showed dilation of the frontal sinus. Computed tomography and magnetic resonance imaging revealed a cystic mass extending into the left orbit and anterior cranial fossa. Gross inspection at the frontal c...

The deferred effects of infant diets and the effects of juvenile diets on cholesterol metabolism were estimated in 83 baboons (Papio sp.) at 3.5 years of age. As infants, the animals were breast-fed or fed one of three formulas containing approximately 2, 30, or 60 mg/dl cholesterol. After weaning at 14 weeks of age, the animals were fed one of four juvenile diets high or low in cholesterol wit...