Pesticides can increase productivity in agriculture. Excessive and uncontrolled use of pesticides pose a risk poisoning farmers. Decreased levels cholinesterase enzymes characterize poisoning. The duration spraying is an indicator that affect the enzyme. This study aimed to determine how long affects enzyme farmers who organophosphate pesticides. Examination using enzymatic test method. most co...

The effect of storage on the catalytic concentration of cholinesterase and on the reference values of cholinesterase in human serum were studied. When serum was stored at room temperature (20 degrees C), at 4 degrees C and at - 20 degrees C (one year) there was no change in catalytic activity. Even after nine times freezing and thawing (over nine weeks) the catalytic activity was unaffected. Th...

cholinergic effects of the fluorophosphates and those of physostigmine was noted by the British workers, McCombie et al.,’ and by Adrian and his group.2 The theory of chemical mediation of the transmission of nerve impulses through the autonomic nervous system identifies ac&ylcholine as the mediator. The presence of the enzyme, cholinesterase, at sites where acetylcholine is liberated by the ne...

cholinergic effects of the fluorophosphates and those of physostigmine was noted by the British workers, McCombie et al.,’ and by Adrian and his group.2 The theory of chemical mediation of the transmission of nerve impulses through the autonomic nervous system identifies ac&ylcholine as the mediator. The presence of the enzyme, cholinesterase, at sites where acetylcholine is liberated by the ne...

Aim & objective: The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of Acacia catechu ethanolic seed extract to introduce a new source for management of Alzheimer’s disease. Background: Alzheimer’s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50–60% of dementia...

An antigenic secretory protein with cholinesterase activity was isolated from the excretory gland cells of Stephanurus dentatus and was purified by gel filtration and ion exchange chromatography. The antigenicity of the cholinesterase was demonstrated by an esterase-active immunoprecipitate formed with S. dentatus antiserum and by the ability of the antiserum to protect the enzyme from heat ina...

Alzheimer disease is characterized by a loss of cholinergic neurons in the basal forebrain and a decrease in acetylcholine levels. Currently, cholinesterase inhibitors, drugs that act by inhibiting the enzyme responsible for the hydrolysis of acetylcholine, are the only therapy for the treatment of Alzheimer disease approved by the Food and Drug Administration. The cholinesterase inhibitors hav...

In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). These derivatives were cha...

Serum cholinesterase activity and the dibucaine numbers have been determined by using a hydrogen peroxide electrode and the enzyme choline oxidase immobilized on a nylon net. The analysis procedure is extremely simple and very fast allowing 30 cholinesterase determinations per hour. Both cholinesterase activity and dibucaine number measurements could be performed in 5 min and by using serum sam...

Parallel studies were made of cholinesterase activities and localizations in denervated rat and rabbit gastrocnemius muscle. Koelle's histochemical reaction was used for demonstrating the localization of cholinesterases. Enzyme activities in whole sliced muscle were measured by electrometric titration. The Cartesian ampulla-diver technique was used for cholinesterase activity determinations in ...