نتایج جستجو برای: chorionic villous sampling

تعداد نتایج: 221506  

2016
Neil J Sebire Philippa C May Baljeet Kaur Michael J Seckl Rosemary A Fisher

BACKGROUND Pregnancies affected by non-molar chromosomal abnormality may sometimes demonstrate abnormal chorionic villous morphology that is similar to partial hydatidiform mole. Determination of the underlying aetiology may be difficult in such cases. CASE PRESENTATION This report describes a case referred to the regional trophoblastic disease unit as a possible hydatidiform mole that demons...

Journal: :Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2014
Hironori Takahashi Kazuya Yuge Shigeki Matsubara Akihide Ohkuchi Tomoyuki Kuwata Rie Usui Mitsuaki Suzuki Toshihiro Takizawa

A disintegrin and metalloproteinases (ADAMs) are members of the metzincin family of zinc-dependent metalloproteinases that play pivotal roles in the proteolytic degradation of the extracellular matrix for cell invasion. Few studies have investigated the ADAM subtypes that are expressed in first trimester trophoblast cells. The purpose of this study was to elucidate the differential expression p...

Journal: :Development 1990
C B Oudejans M Pannese A Simeone C J Meijer E Boncinelli

Human first trimester extraembryonic tissues of normal and androgenetic origin (molar pregnancies) were investigated for the expression of 6 homeobox genes from the chromosome 12-encoded Hox-3 cluster by non-autoradiographic in situ hybridization with biotinylated RNA probes. By comparative in situ hybridization involving the use of exon- or region-specific RNA probes, analysis included the cel...

Journal: :The Journal of clinical investigation 1993
P D Arkwright T W Rademacher R A Dwek C W Redman

Pre-eclampsia is a placental disorder, but until now, biochemical details of dysfunction have been lacking. During an analysis of the oligosaccharide content of syncytiotrophoblast microvesicles purified from the placental chorionic villi of 10 primigravid women with proteinuric pre-eclampsia, we found an excess of glycogen breakdown products. Further investigation revealed a 10-fold increase i...

2015
Lucy E. Higgins Nicolas Rey de Castro Naa Addo Mark Wareing Susan L. Greenwood Rebecca L. Jones Colin P. Sibley Edward D. Johnstone Alexander E. P. Heazell Manu Vatish

OBJECTIVE Currently, no investigations reliably identify placental dysfunction in late pregnancy. To facilitate the development of such investigations we aimed to identify placental features that differ between normal and adverse outcome in late pregnancy in a group of pregnancies with reduced fetal movement. METHODS Following third trimester presentation with reduced fetal movement (N = 100)...

Journal: :Molecular human reproduction 2001
D Marzioni M Banita A Felici F J Paradinas E Newlands M De Nictolis J Mühlhauser M Castellucci

Zonula occludens-1 (ZO-1) and occludin are key molecules in cell-cell contacts. They are tight junction constituents and therefore play a pivotal role in tissue differentiation and organogenesis. In the present report we have investigated the expression of ZO-1 and occludin in normal human placentae and in hydatidiform moles using immunohistochemical and Western blot analyses. In normal placent...

Journal: :Human reproduction 1997
M E Palmer A L Watson G J Burton

We have recently shown using dansyl-L-lysine exclusion studies that the release of human chorionic gonadotrophin (HCG) in conjunction with L-lactate dehydrogenase (LDH) from first trimester villi during organ culture is symptomatic of syncytiotrophoblast degeneration. The purpose of this study was to examine chorionic villi at the ultrastructural level in order to determine events occurring dur...

Journal: :Ultrasound in Obstetrics and Gynecology 2001

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