Chorionic villus sampling (CVS) and amniocentesis are prenatal diagnostic procedures that are performed to detect fetal abnormalities. In 1991, concerns about the relative safety of these procedures arose after reports were published that described a possible association between CVS and birth defects in infants. Subsequent studies support the hypothesis that CVS can cause transverse limb defici...

This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study relate to the following: sampling method, referral reason versus abnormality an...

A complete mole coexisting with dichorionic twins was diagnosed by the combined use of sonography and chorionic villus sampling at 10 weeks gestation. The pregnancy resulted in the death of one fetus at 31 weeks from presumed feto-maternal haemorrhage, while the other fetus survived in good condition. A summary of the available literature, combined with this report, reveals a total of seven pre...

Methods From January 2013 to December 2015, we included 107 chorionic villus sampling sample from consecutive ongoing gestation, with combine test risk >1/270, fetal NT˃3. 5mm, NB(-), DV(+), TR(+) and structure abnormalities at 11-13 weeks' gestation, from a regional hospital. Subsequently, 93 amniocentesis sampling was performed when the structure abnormalities finding by ultrasonography scans...

In the last ten years, placenta, fetal membranes (i.e. amnion and chorion), and amniotic fluid have been extensively investigated as a potential non-controversial source of stem cells. They are usually discarded after delivery and are accessible during pregnancy through amniocentesis and chorionic villus sampling [1] Several populations of cells with multi-lineage differentiation potential and ...

Brambati, Simoni, and Fabro have provided us with an excellent discussion of the many aspects of chorionic villus sampling in this book. In addition to a thorough review of the historical, technical, and practical elements of the procedure, attention has been directed to the social and ethical issues surrounding this valuable and new means of addressing the fetal patient. Bernadette Modell also...