OBJECTIVE There are few health-related quality of life (HRQOL) instruments available that have been validated for use with Turkish children. The Kid-KINDL is a generic measure of children's (8-12 years) HRQOL, which contains 24 categorical items that assess 6 dimensions (physical well-being, emotional well-being, self-esteem, family, friends, and school). The Kid-KINDL is available in many lang...

Dmitri Mogilevtsev,1,2 Yong Siah Teo,3 Jaroslav Řeháček,3 Zdeněk Hradil,3 Johannes Tiedau,4 Regina Kruse,4 Georg Harder,4 Christine Silberhorn,4,5 and Luis L. Sánchez-Soto5,6 1Institute of Physics, Belarus National Academy of Sciences, F. Skarina Ave. 68, Minsk 220072 Belarus 2Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP, 09210-170 Brazil 3Department of Op...

We have performed a 4-μs molecular dynamics simulation to investigate the native conformational preferences of the intrinsically disordered kinase-inducible domain (KID) of the transcription factor CREB in solution. There is solid experimental evidence showing that KID does not possess a bound-like structure in solution; however, it has been proposed that coil-to-helix transitions upon binding ...

Christine: [...] I think everything has feelings. Even a piece of stone that was carved all those years ago. I feel that it's, well they made it a living thing didn't they? Siân: Mmmm Christine: When they did that. Siân: Yes, when they created it? Christine: Yes. They made a living thing. So I feel, yes, I think when it goes back into the ground it will be home. Siân: Yes, that's really interes...

The parD operon of Escherichia coli plasmid R1 encodes a toxin-antitoxin system, which is involved in plasmid stabilization. The toxin Kid inhibits cell growth by RNA degradation and its action is neutralized by the formation of a tight complex with the antitoxin Kis. A fascinating but poorly understood aspect of the kid-kis system is its autoregulation at the transcriptional level. Using macro...

Keratitis-ichthyosis-deafness (KID) syndrome is an ectodermal dysplasia caused by dominant mutations of connexin26 (Cx26). Loss of Cx26 function causes nonsyndromic sensorineural deafness, without consequence in the epidermis. Functional analyses have revealed that a majority of KID-causing mutations confer a novel expansion of hemichannel activity, mediated by connexin channels in a nonjunctio...

SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported that SIAH-1 induces the degradation of Kid (KIF22), a chromokinesin protein implicated in the normal progression of mitosis and meiosis, by the ubiquitin proteasome pathway. In human breast ...