Interchromosomal distributions of breakpoints from chromatidtype aberrations induced by gamma rays in Chinese hamster ovary (CHO) cells were analyzed. In most chromosomes the distribution was as expected from chromosome lengths for simple breaks or the respective relative corrected length in case of exchanges. There were deviations from expectation in a few chromosomes for chromatid breaks, int...

OBJECTIVE Concerns were raised about the potential damaging effects of electromagnetic field (EMF) radiation emissions of ELF (extremely low frequency) and VLF (very low frequency) computer video display monitors (VDM), it was assessed the frequency of structural chromosome abnormalities and investigated the cell cycle kinetics in individuals occupationally exposed to VDM radiation. METHODS C...

Cornelia de Lange syndrome (CdLS) is a rare dominantly inherited multisystem disorder affecting both physical and mental development. Heterozygous mutations in the NIPBL gene were found in about half of CdLS cases. Scc2, the fungal ortholog of the NIPBL gene product, is essential for establishing sister chromatid cohesion. In yeast, the absence of cohesion leads to chromosome mis-segregation an...

In this study, we compared cross-bred dairy cows in the Susa Valley (Piedmont, northern Italy), reared either near a high-temperature steel production plant (Farms A and B) or in an industry-free area (control). Exposed cows (n = 36) were selected based on mean bulk milk toxic equivalent values of polychlorodibenzodioxins (PCDDs) and dioxin-like (DL) polychlorobiphenyls (PCBs) and polychlorodib...

introduction: this study was performed to analyze chromosomal aletrations in g1 and g2 immortalizedmolt-4 cell line following treatment with methotrexate (mtx) and cytarabine (ara-c) alone or incombination. material and methods: molt-4 cells were cultured and manitained in rpmi-1640 supplementedwith fetal calf serum, antibiotics and l-gluthamine. cells were treated with ara-c and mtx with aconc...

The antitumor drug Etoposide (ETO) induces DNA double-strand breaks (DSB) and is associated with the development of secondary neoplasms in treated patients. DSB are repaired by two main mechanisms, homologous recombination (HR) classical non-homologous end joining (c-NHEJ). When HR c-NHEJ defective, PARP-1-dependent alternative end-joining (alt-EJ) pathway. involvement alt-EJ progression induce...