Key References 1. De Ridder D, Geenen R, Kuijer R, et al. Psychological adjustment to chronic disease. Lancet 2008;372:246–55. 2. Guidelines for the evaluation and treatment of depression of the National Institute for Health and Clinical Excellence (NICE). 3. Dickens C, McGowan L, Clark-Carter D, et al. Depression in rheumatoid arthritis: a systematic review of the literature with meta-analysis...

BACKGROUND Information on arthritis and other musculoskeletal disorders among Aboriginal people is sparse. Survey data show that arthritis and rheumatism are among the most commonly reported chronic conditions and their prevalence is higher than among non-Aboriginal people. OBJECTIVE To describe the burden of arthritis among Aboriginal people in northern Canada and demonstrate the public heal...

A protective and anti-inflammatory role for CD1d-dependent NKT cells (NKTs) has been reported in experimental and human autoimmune diseases. However, their role in arthritis has been unclear, with conflicting reports of CD1d-dependent NKTs acting both as regulatory and disease-promoting cells in arthritis. These differing modes of action might be due to genetic differences of inbred mice and in...

Arthritis is the most common cause of disability among U.S. adults and is particularly common among persons with multiple chronic conditions. In 2003, arthritis in the United States resulted in an estimated $128 billion in medical-care costs and lost earnings. To update previous U.S. estimates of the prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation (AAAL),...

Classification Chronic idiopathic arthritis of childhood encompasses a diverse group of disorders. This diversity is reflected in the diVerent classification systems in use in North America and Europe. 2 As concepts have evolved there have been attempts to modify the classification system. This is not just a matter of semantics, but a recognition that it is necessary to develop as much homogene...

Microbes reach the synovial cavity either directly during bacteraemia or by transport within lymphoid cells or monocytes. This may stimulate the immune system excessively, triggering arthritis. Some forms of ReA correspond to slow infectious arthritis due to the persistence of microbes and some to an infection triggered arthritis linked to an extra-articular site of infection.

BACKGROUND To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several laboratories worldwide to establish a series of protocols for different animal models of arthritis that reflect the pathogenesis of RA. Here, we describe chronic pristane-induced arthritis (PIA) model in DA rats, and provide det...

BACKGROUND Information on arthritis and other musculoskeletal disorders among Aboriginal people is sparse. Survey data show that arthritis and rheumatism are among the most commonly reported chronic conditions and their prevalence is higher than among non-Aboriginal people. OBJECTIVE To describe the burden of arthritis among Aboriginal people in northern Canada and demonstrate the public heal...