background many types of cardiovascular complications such as; cardiac arrhythmias, impaired cardiac function, myocardial ischemia and decreased left ventricular function, have been attributed to interferon therapy. objectives the aim of this study was to evaluate the effects of combination therapy pegylated interferon and ribavirin on left ventricular systolic and diastolic functions in patien...

results our results revealed that the serum levels of tgf-β were significantly increased in chb patients in compare to healthy controls. conclusions according to this result, it may be concluded that high serum levels of tgf-β may be a mechanism by which immune response against hbv is suppressed. background the transforming growth factor-β (tgf-β) is an important cytokine with anti-inflammatory...

background hbv infection is a serious public health problem worldwide, which can contribute to the incidence of chronic hepatitis b (chb), cirrhosis, and hepatocellular carcinoma (hcc). objectives in the present report, we assessed the association between adiponectin, its receptors and hepatic steatosis, fibrosis, and inflammation with hepatitis b virus. patients and methods liver biopsies from...

conclusions this study revealed that serum iron markers (especially ferritin and transferrin) might be used as surrogate markers for both liver fibrosis and necroinflammatory activity. patients and methods eighty five patients with untreated hepatitis c chronic infection were investigated. . results twenty one patients (24.7%) had elevated serum iron levels, and 29 subjects (34.1%) had severe l...

background the prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis b observed in poland. objectives we aimed to determine the chronic hepatitis b incidence trends in poland, taking into consideration the ages, genders, and environments of the patients. methods the study is based on aggregated data from polish descriptive epidemiologic...

background: available drugs are not able to eradicate intracellular viral dna in patients with hepatitis b virus (hbv) infections. hbsag vaccine could induce immunity and subsequently eradicate hepatitis b virus in proportions of these patients. our aim was to evaluate the efficacy of hbsag as a mode of therapy in inactive carriers. materials and methods: forty two consecutive patients of inact...

conclusions it appears that anti-hav antibody seroprevalence has declined among children below 15 years with and without chronic liver disease, and it is likely that more children would be susceptible to hav infection. therefore, it is important to employ preventative strategies against hav in chronic liver diseases. results seroprevalence of hav was 17.8% and 10% in the first and second study,...

Autoimmune hepatitis is (AIH) is a chronic hepatitis that occurs in children and adults of all ages. It is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. It was first described in the 1950s by term of chronic active hepatitis. It has 2 types with different auto antibodies. Diagnosis is based upon serologic and ...