Behçet's disease (BD) is a chronic inflammatory condition involving several organs, such as skin, mucous membrane, eye, joint, intestine, lung and central nervous system. Ankylosing spondylitis (AS) is a prototype of seronegative spondyloarthropathy, and a chronic systemic inflammatory disorder of the axial skeleton, mainly affecting the sacroiliac joint and spine. In the latter, systemic compl...

Inflammatory bowel disease (IBD) is comprised of both ulcerative colitis (UC) and Crohn's disease (CD) and is a chronic inflammatory disorder that results from a dysregulated immune response in genetically susceptible individuals. Data from genome-wide association studies (GWAS) have identified approximately 70 genetic loci that confer susceptibility to CD and over 30 loci that are associated w...

Metabolic syndrome is a compound obesity disorder, wherein the abnormal metabolism of glucose and lipid is associated with the development of chronic inflammatory diseases. The prevalence of this disease is increasing in the developed world, but the causative linkage between these metabolic disorders has remained obscure. Metabolic disease may be associated with chronic nucleotide secretion, pu...

Psoriasis is a chronic inflammatory disorder characterized by T cell dysregulation and a chronic inflammatory infiltrate within the epidermis. Several cytokines play an important role in the pathogenesis of psoriasis, including interleukin-12 (IL-12) and IL-23. These cytokines act via induction of pro-inflammatory cytokines which promote chronic inflammation and auto-reactivity. Ustekinumab is ...

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinical...

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative s...

Asthma is a serious public health problem in New York as well as the rest of the nation. Asthma is a chronic inflammatory disorder of the airways characterized by intermittent, recurrent episodes of wheezing, breathlessness, chest tightness, and cough. The airways of people with asthma often exhibit mucosal edema, epithelial disruption, and infiltration with inflammatory cells. Asthma is the mo...

Background: Cynara cardunculus L. var. altilis (DC) is a plant generally associated as an ingredient in the Mediterranean diet. The polyphenols present this provide pharmacological and nutritional properties. C. has been used throughout animal studies, which demonstrated anti-inflammatory effect. Inflammatory bowel disease (IBD) chronic inflammatory disorder of gastrointestinal tract. Since the...

Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and one of the main diabetic microvascular complications. As number patients grows, DN has become leading cause chronic disease in China. Unfortunately, no definitive cure currently exists for DN. Cornus officinalis (CO), frequently utilized clinical settings mellitus treatment, proven vital both preventing treating This artic...

Alterations in the immune system are often found children with Autism Spectrum Disorders [ASD], leading to an aberrant response which compromises host defense. Fewer regulatory T-cells, elevation inflammatory cells and proinflammatory cytokines have been highly reported this population it has recently seen as a chronic neuroinflammatory disorder. Cytokines dysregulated ASD especially IL-6, is o...