نتایج جستجو برای: chronic mucocutaneous

تعداد نتایج: 499713  

Journal: :British medical journal 1978
J W Van Der Meer P C Leijh Van Den Barselaar R Van Furth

147 rates increasing only slightly over the same 30-beat period. These diabetics had other evidence of vagal damage, with abnormal responses to the Valsalva manoeuvre and reduced R-R interval variation. The results of the drug studies on the three controls confirm that the reflex is mediated through the vagus. In 1895 Hill8 suggested that changes in posture might provide a "most delicate test o...

Journal: :European Journal of Internal Medicine 2018

Journal: :Archives of Dermatology 2006

Journal: :Proceedings of the Royal Society of Medicine 1973

Journal: :Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2004
Shih-Jung Chiu Ching-Hsiung Tsao Li-Chen Chen Chun-Chieh Kao Ko-Huang Lue Jing-Long Huang

Chronic mucocutaneous candidiasis (CMC) is a complex disorder characterized by persistent or recurrent candidal infections of the skin, nails and/or mucous membranes. A familial occurrence has been reported in some instances, suggesting a genetic predisposition. CMC has also been suggested to be associated with a selective defect in T cell-mediated immunity to Candida antigens. Reports of cases...

Journal: :Iranian journal of allergy, asthma, and immunology 2005
Mohammad Reza Fazlollahi Abolhassan Farhoudi Masoud Movahedi Mohammad Gharagozlou Kourosh Mohammadi Nima Rezaei

Chronic Mucocutaneous Candidiasis (CMCC) refers to a group of immunodeficiencies, characterized by persistent or recurrent infections of the skin, nails, and mucus membranes caused by candida. A wide range of immunologic abnormality has been reported in CMCC. Defects in cellular limb of the immune system, mainly the specific response to antigens of candida species, are well documented in CMCC p...

Journal: :The New England journal of medicine 2011
Frank L van de Veerdonk Theo S Plantinga Alexander Hoischen Sanne P Smeekens Leo A B Joosten Christian Gilissen Peer Arts Diana C Rosentul Andrew J Carmichael Chantal A A Smits-van der Graaf Bart Jan Kullberg Jos W M van der Meer Desa Lilic Joris A Veltman Mihai G Netea

BACKGROUND Chronic mucocutaneous candidiasis (CMC) is characterized by susceptibility to candida infection of skin, nails, and mucous membranes. Patients with recessive CMC and autoimmunity have mutations in the autoimmune regulator AIRE. The cause of autosomal dominant CMC is unknown. METHODS We evaluated 14 patients from five families with autosomal dominant CMC. We incubated their peripher...

2017
Yousef R Badran Fatma Dedeoglu Juan Manuel Leyva Castillo Wayne Bainter Toshiro K Ohsumi Athos Bousvaros Jeffrey D Goldsmith Raif S Geha Janet Chou

The treatment of chronic mucocutaneous ulceration is challenging, and only some patients respond selectively to inhibitors of tumor necrosis factor-α (TNF). TNF activates opposing pathways leading to caspase-8-mediated apoptosis as well as nuclear factor κB (NF-κB)-dependent cell survival. We investigated the etiology of autosomal-dominant, mucocutaneous ulceration in a family whose proband was...

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