Background: Stress predisposes organisms to depression and cognitive impairments, and seems to interact with metabolic homeostasis. The inflammatory response and the upregulation of proinflammatory cytokines are some of the consequences related to chronic stress. In this study, we investigated the preventive effect of chronic administration of ibuprofen, as an inhibitor of cyclooxygenases, on t...

background: multiple sclerosis (ms) is one of the most common chronic diseases of the central nervous system. the aim of this study was to determine the effectiveness of psychological training combined‎ with gradual muscular stress relaxation technique on qol of patients with ms. materials and methods: this triple-blind, controlled, clinical trial was conducted on 60 patients with ms who were m...

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since industrial revolution heavy metals such as lead (pb) and cadmium (cd) have been extensively dispersed in environment which, unknown biological effects and prolong biological half-life make them as a major hazard to human health. in addition, the sharp increase in multiple sclerosis incidence rates has been recorded in iran. the propose of this study was to measuring blood lead and cadmium...

Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis. The purpose of this study was to determine whether psychological stress increases ex vivo cytokine production or decreases glucocorticoid sensitivi...

results in the current study, no statistically significant differences were found between the study groups in demographic variables (p > 0.05). analysis of covariance revealed significant differences between the study groups in all the 3 variables in posttest compared to the pretest. the mean scores of depression, anxiety, and stress in the micbt group were significantly lower than the control ...

objective(s):multiple sclerosis (ms) is a demyelinating disease. the prevalence of ms is highest where environmental supplies of vitamin d are low. cognitive deficits have been observed in patients with ms. oxidative damage may contribute to the formation of ms lesions. considering the involvement of hippocampus in ms, an attempt is made in this study to investigate the effects of vitamin d3 on...

This study of depressed outpatients (N=47) examined self-criticism (SC) and personal standards (PS) dimensions of perfectionism as moderators of the relation between chronic stress and depression over 1year. Participants completed personality measures (SC, PS, neuroticism, conscientiousness) at baseline (Time 1), a chronic stress interview 6months later (Time 2), and self-report and interviewer...

Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation and oxidative stress, with its role in OSA-induced lung injury being unclear. This study aimed to investigate the beneficial effect of tempol on chronic intermittent hypoxia (IH)-induced lung injury....