chronic urticaria is defined as a skin disease with central induration (wheal) and erythema formation around it (flare) that appears at least twice a week and remains at least for 6 weeks continually. the incidence of urticaria in children is about 0.1-3%. most cases of chronic urticaria occur in children between 6-11 years. autoimmune and allergy immaturity is one of the reasons of lower incid...