In the framework of an integral assessment (effectiveness and cost) of the use of neuroprotection in stroke, a cost-effectiveness study was conducted to compare the potential advantages of citicoline with conventional therapy (without neuroprotection or placebo) in patients with acute ischemic stroke. The literature was searched for systematic reviews and meta-analyses evaluating the effectiven...

A simple, accurate, precise and sensitive reverse-phase high-performance liquid chromatography method for the determination of citicoline sodium has been developed and validated. Drug was resolved on a C18 column (Phenomenex Luna, 250×4.6 mm, 10μ), utilizing mobile phase of potassium dihydrogen phosphate buffer and acetonitrile in a ratio of 30:70. Mobile phase was delivered at the flow rate of...

AIM The aim of this study was to investigate the dose dependence of citicoline's previously-reported effects on recovery of peripheral nerve injury. MATERIAL AND METHODS Right sciatic nerves of sixty adult female Wistar Albino rats were incised and primary anastomosis was performed. Rats were then divided into four groups: Control group received 2 ml of saline intraperitoneally, while rats in...

A significant percentage of elderly subjects (50%-80%) suffering from sub-acute ischemic cerebrovascular disease, with or without moderate or severe cognitive memory decline and with or without associated behavioral and psychological symptoms, shows a complex syndrome. This syndrome is related to the progressive impairment of health conditions and/or stressing events (ie, hospitalization), char...

A validated, specific, stability indicating reversed-phase liquid chromatographic method has been developed for quantitative analysis of citicoline and its related substances in oral drops formulation. Forced degradation studies were performed using acidic, basic and oxidizing conditions, and thermal and photolytic stress, to show the stability indicating power of the method. The method was opt...

Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There a need to diminish morbidity related with TBI and improve outcome patients suffering TBI. Among improvements in treatment TBI, neuroprotection one upcoming improvements. Citicoline has been used management brain ischemia disorders, such as biochemical, pharmacological, pharmacokine...

Pharmacological treatment of cerebrovascular disorders was introduced at the beginning of the 20th Century. Since then, a multitude of studies have focused on the development of a consensus for a well defined taxonomy of these disorders and on the identification of specific patterns of cognitive deficits associated with them, but with no clear consensus. Nevertheless, citicoline has proved to b...

This study aims to assess 1000 mg citicoline each day given for 60 days on chronic phase NAION (non–arteritic anterior ischemic optic neuropathy) patients. Double masked randomized clinical trial divided the patients into 2 groups: group (C–NAION) and placebo (P–NAION). Analysis was done in 17 group. There were increament of ? amplitude P50 30 C–NAION (0,775±2,6 µV) N95 (–0,356±2,992 but statis...