Abstract Background Sparse relative effectiveness evidence is a frequent problem in Health Technology Assessment (HTA). Where directly pertaining to the decision sparse, it may be feasible expand evidence-base include studies that relate only indirectly: for instance, when there no on comparator, other treatments of same molecular class could used; similarly, children borrow-strength from adult...

regarding the necessity of regional integrated development, analyzing the dependency of human habitats in region-level, is the main duty in every planning. therefore, deprivation and inequality reduction is an important matter, due to its economic and social consequences and needs proper attention. in fact, to achieve comprehensive development and progress in the future; requires the recognitio...