Time-kill studies compared the activities of grepafloxacin with those of ciprofloxacin, levofloxacin, sparfloxacin, amoxicillin-clavulanate, and clarithromycin against 12 pneumococcal strains. Grepafloxacin was bactericidal after 24 h against all strains at a concentration of < or = 0.5 microg/ml, while sparfloxacin, levofloxacin, and ciprofloxacin were bactericidal at concentrations of < or = ...

The prevalence of antimicrobial resistance among 4,940 U.S. pneumococcal isolates collected during 1999 was as follows: penicillin, 16.2%; amoxicillin-clavulanate, 12.2%; cefuroxime, 28.1%; ceftriaxone, 3.6%; trimethoprim-sulfamethoxazole, 30.3%; azithromycin, 21.4%; levofloxacin, 0.6%; and moxifloxacin, 0.1%. Compared to the previous 1997-1998 study (Jones et al., Antimicrob. Agents Chemother....

In order to discuss a role of antibiotics, a 73-year old patient was presented, having an exacerbation of Chronic Ob- structive Pulmonary Disease (COPD) and to whom amoxicillin/clavulanate antibiotic was prescribed. Literature search has indicated that antibiotics are recommended for COPD patients in two cases. Firstly, they are recommended in the patients having an acute exacerbation with incr...

Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) microgram/ml. Amoxicillin, temafloxacin, and cl...

Non-derivative and derivative UV spectrophotometric techniques using water as solvent have been developed for the simultaneous determination of amoxicillin and clavulanate in combined tablets. For UV spectrophotometric techniques, the concentrations of amoxicillin and clavulanate in conformity with the Lambert-Beer law are 100.0 – 160.0 mg/ml and 10.0 – 35.0 mg/ml, respectively. The derivative ...

Mycobacterium tuberculosis strains resistant to almost all available anti-tuberculosis drugs are an increasing threat to public health worldwide. Among existing drugs with potential antimycobacterial effects, the combination of meropenem with clavulanate has been shown to have potent in vitro bactericidal activity against extensively drug-resistant tuberculosis (XDR-TB). To explore its potentia...

The aim of this study was to determine differences in residue elimination of amoxicillin (AMX) in cow ́s milk, after intramammary administration of a pharmaceutical preparation of AMX plus potassium clavulanate (CLV), either in healthy or in spontaneous cases of clinical mastitis, and following label instructions or administering the preparation in an extra-label manner. Twelve lactating healthy...

BACKGROUND Macrolide antibiotics are often used to treat children with acute otitis media (AOM); however, the 2004 American Academy of Pediatrics (AAP) and American Academy of Family Physicians guidelines recommend against their use in patients without history of a type I allergic reaction to penicillins. OBJECTIVE To evaluate via meta-analysis the comparative efficacy of amoxicillin or amoxi...

INTRODUCTION Despite the advanced antibiotic therapies, sepsis continues being a clinical entity with high morbidity and mortality. The ozone/oxygen mixture (O3/O2) has been reported to exhibit positive effects on immunity. The aim of our study was to analyze whether (O3/O2) combined with amoxicillin/clavulanate has any influence on the morbidity and mortality of septic rats. METHODS We used ...