An estimated 16 million people in the United States have coronary artery disease (CAD), and approximately 325,000 people die annually from cardiac arrest. About two-thirds of unexpected cardiac deaths occur without prior recognition of cardiac disease. A vast majority of these deaths are attributable to the rupture of 'vulnerable atherosclerotic plaques'. Clinically, plaque vulnerability is typ...

A 54-year-old man was referred to our department for colorectal cancer screening. The colonoscopy revealed, at the ascending colon, several white plaques, some confluent, interspersed with normal mucosa (Fig. 1). Biopsies were performed and the histopathological examination showed a fragment of polypoid colonic mucosa with optically empty vacuoles in the lamina propria (Fig. 2) and irregular cy...

NLY a few instances of well defined mutation have been described for 0 the bacteriophages. The best known form a class of mutations affecting host range, recently studied by LURIA (1945a, 1g45b), whose papers may be consulted also for mention of the earlier literature. This paper is concerned with a second class of mutations, occurring within single plaques of certain coli-dysentery phages, whe...

Background The study was designed to verify the concept of plaques "at risk" and whether inflammation could play a role in plaque rupture and thrombosis. Methods and Results In 20 patients who had died of acute myocardial infarction, the thrombosed coronary artery was identified and the site of plaque rupture was traced in serial sections. The cellular characteristics of the fibrous cap at the ...

Alzheimer's disease (AD) is defined by senile plaques made of amyloid-beta peptide (Abeta), neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits. Thus, the events initiating the cascade leading to these end points may be more effective therapeutic targets than treating each facet individually. In the small percentage of cases of AD that are genetic (or animal mo...

Over the past 25 years, it has become clear that the proteins forming the deposits are central to the disease process. Amyloid-ß and tau make up the plaques and tangles of Alzheimer’s disease(AD), where these normally soluble proteins assemble into amyloid-like filaments(Michel and Maria, 2006). Recently Ballatore et al. (2007) summarized the most recent advances in the mechanisms of tau-mediat...

Information processing in the retina starts at the first synaptic layer, where photoreceptors and second-order neurons exhibit a complex architecture of glutamatergic and electrical synapses. To investigate the composition of this highly organized synaptic network, we determined the spatial relationship of zonula occludens-1 (ZO-1) with different connexins (Cx) and glutamate receptor (GluR) sub...

ObjectiveDynamic image analysis of carotid plaques has demonstrated that during systole and early diastole, all plaque components will move in the same direction (concordant motion) some plaques. However, others, different parts directions (discordant motion). The aim our study was (1) to determine prevalence discordant motion symptomatic asymptomatic plaques, (2) develop a measurement severity...