Cleft lip and palate is one of the most common birth defects occurring 1 of every 700 live births. Historically, cleft lip and palate care typically involves the use of presurgical infant orthopedics appliances (PIOA) fabricated by a pediatric dentist as an adjunct to the overall management of the defect approximate the cleft segments prior to surgical repair. However, the necessity of presurgi...

Background and objectives: Cleft lip palate deformity is one of the highly frequent most difficult problems arising in orthodontic clinics, associated with these deformities dental anomalies presented as defect number eruption process, this study aimed to find prevalence cleft patients Erbil city. Method: One hundred orthopantomograms out 167 examined by a well-trained orthodontist for presence...

In mammals, embryonic development are highly regulated morphogenetic processes that are tightly controlled by genetic elements. Failure of any one of these processes can result in embryonic malformation. The lysyl oxidase (LOX) family genes are closely related to human diseases. In this study, we investigated the essential role of lysyl oxidase-like 3 (LOXL3), a member of the LOX family, in emb...

Among facial esthetic surgeons, secondary rhinoplasty in adult cleft –nose deformities is considered to be one of the most challenging surgical interventions due to the congenital distortion of the cartilaginous and bony nasal pyramid, which compromises both nasal esthetics and function. It is generally accepted that the cleft-lip nasal deformity (CLND) is challenging; It is attempted to do thi...

Unilateral cleft lip nasal deformity is characterized by prominent asymmetry resulting from distorted and displaced structures. Primary correction of the nasal deformity at the same time of lip repair has gained popularity, aiming at early restoration of the symmetry by lifting the alar cartilage and lengthening the columella on the cleft side. Postoperative relapse is a frequent finding due to...

UNLABELLED Patients with unilateral cleft lip display characteristic nasal changes that are independent of the degree of deformity. Defenders of the intrinsic theory consider these deformities to be due to embryogenic alterations of the alar nasal cartilages. Those that propose the extrinsic theory defend the thesis that the deformity is due to disorganization of the perioral muscles deformed b...

The anatomical studies of Veau laid the foundation for our present understanding of cleft lip and palate (Veau, 1926, 1931, 1935). His embryologic research into the pathogenesis of cleft lip and palate in the human is a classic study (Veau and Politzer, 1936). Veau recognized that unilateral and bilateral cleft conditions showed a characteristic skeletal deformity that was consistently uniform ...

Presurgical orthopedics forms an integral part of the treatment of patients with facial clefting. The primary aim of presurgical nasoalveolar moulding (PNAM) is reduction in the soft tissue and cartilaginous deformity to facilitate surgical soft tissue repair in optimal conditions under minimum tension to minimize scar formation. It also helps in reducing the nasal deformity with a nasal stent ...

OBJECTIVE To determine if Chinese individuals with non syndromic cleft lip with or without cleft palate (CL/P) display more dermatoglyphic asymmetry than unaffected relatives or controls. DESIGN Case-control study with two control groups (genetically related and unrelated). SETTING AND SAMPLE POPULATION A total of 500 CL/P probands from Shanghai, China, 421 unaffected relatives, and 66 cont...

To cite: Harb A, Shawwa K, Alraiyes AH, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013009884 DESCRIPTION A 49-year-old woman with a medical history of hypertension and rheumatoid arthritis presented with severe bilateral hand pain due to arthritis. She was diagnosed with rheumatoid arthritis at the age of 20 years and has been on anti-inflammatory med...