Phelan, P. D., Stocks, J. G., Williams, H. E., and Danks, D. M. (1973). Archives of Disease in Childhood, 48, 275. Familial occurrence of congenital laryngeal clefts. Two sibships of double first cousins in which 6 children had congenital laryngeal anomalies are reported. 3 of the children had proven congenital posterior laryngeal clefts, 1 had subglottic stenosis with a deformed cricoid cartil...

Objective. Few orofacial cleft (OFC) studies have examined the severity of clefts of the lip or palate. This study examined associations between the severity of cleft of the lip with cleft type, laterality, and sex in four regional British Isles cleft registers whilst also looking for regional variations. Design. Retrospective analysis of cleft classification in the data contained in these four...

Research on oral clefts has noticeably grown over the past two decades to cover its various aspects, including etiology, epidemiology, prevention, treatments, health services, and health and socioeconomic outcomes of patients and families. Researchers from multiple disciplines have joined efforts to investigate these complex areas. Brazil provides a unique setting for these studies for several ...

EEC syndrome is an autosomal dominant disorder with the cardinal signs of ectrodactyly, ectodermal dysplasia, and orofacial clefts. EEC syndrome has been linked to chromosome 3q27 and heterozygous p63 mutations were detected in unrelated EEC families. In addition, homozygous p63 null mice exhibit craniofacial abnormalities, limb truncations, and absence of epidermal appendages, such as hair fol...

The purpose of this study was to investigate crown morphologic abnormalities in the permanent dentition of subjects with clefts and unaffected controls. This is a prospective study of 100 patients and 60 control subjects. The study was carried out at the Cleft Lip and Palate Center at the King Abdullah University Hospital and at the Maxillofacial Unit at Jordan University of Science and Technol...

We report a small cohort of patients with severe osteoporotic fractures treated with vertebroplasty. We note a high prevalence of small, central, intraosseous clefts in these severe fractures. Rather than filling the small amount of residual bone marrow around the periphery of these severe fractures, as suggested by previous authors, we suggest central needle placement to fill these central cle...

We report a case of an isolated cleft mitral valve with two clefts in the posterior leaflet. Our case adds to the few reports of posterior and multiple mitral valve clefts and, to our knowledge, is one of the first using real-time transoesophageal three-dimensional echocardiography for the assessment of isolated cleft mitral valve.

Relevance. Anatomical and functional disorders in congenital clefts may be various. Their severity depends on the cleft size combination of a lip with an alveolar cleft. Alveolar bone grafting (ACBG) is one most important surgeries for patients palate rehabilitation. The study aimed to analyze results various age groups, summarizing available data supplementing them our own experience. Material...

OBJECTIVES To present descriptive epidemiology of Orofacial Clefts and to determine the association of syndromic forms with antenatal high-risk conditions, preterm birth, and comorbidities among nested-series of cases. METHODS A study of nested-series of cases was conducted. Frequencies of cleft type, associated congenital anomalies, syndromic, non-syndromic and multiple malformation forms, a...

Malaria parasites export proteins beyond their own plasma membrane to locations in the red blood cells in which they reside. Maurer's clefts are parasite-derived structures within the host cell cytoplasm that are thought to function as a sorting compartment between the parasite and the erythrocyte membrane. However, the genesis of this compartment and the signals directing proteins to the Maure...