Misonidazole (MIS) is a hypoxic cell radiosensitizer currently undergoing Phase III clinical trials in the treatment of cancer by radiation. It is also a cytotoxic agent with specificity toward hypoxic cells, and consequently has a tumoricidal effect in laboratory animals. This tumoricidal effect has not been clini cally applicable, in part because the initial resistance to the cytotoxic action...

Automated Interpretation of Diagnosti Images: The AIDI-Heart Proje t Mattias Ohlsson, PhD1, Andreas J arund2, Lars Edenbrandt, MD, PhD2 1 Department of Theoreti al Physi s, Lund University, Sweden, mattias thep.lu.se 2 Department of Clini al Physiology, Lund University, Sweden http://ism.thep.lu.se/ Abstra t. This paper presents AIDI-Heart, a omputer-based de ision support tool for automated i...

Our space came into existence by the Big Bang, a huge explosion of the singularity. Nowadays we are living in the middle of the second explosion, explosion of information and guidelines. During our professional lives we are looking for information all the time and the ability to find information quickly and efficiently and to process it correctly is highly appreciated. Guidelines are a form of ...

In image-guided radiotherapy (IGRT) of prostate cancer, delineation of the clini-cal target volume (CTV) often relies on magnetic resonance (MR) because of its good soft-tissue visualization. Registration of MR and computed tomography (CT) is required in order to add this accurate delineation to the dose planning CT. An automatic approach for local MR-CT registration of the prostate has previou...

INTRODUCTION Various conventional phenotypic methods and automated systems have been evaluated for extended-spectrum beta-lactamase (ESBL) detection. There is a paucity of data comparing these methods using the same clinical isolates in eastern and north-eastern parts of India. The present study was designed to compare the capacity of six phenotypic methods to detect ESBLs in clinical isolates ...

Chronic obstructive pulmonary disease (COPD) with severe emphysema is a continuously progressing disease, resulting in respiratory failure. Pharmacological treatment may be optimised in the last years, but only the introduction of long-term oxygen treatment has revealed an improvement in survival for patients with advanced COPD [1]. Noninvasive positive pressure ventilation (NPPV) is a new appr...

IN HEALTH CARE H ealth care is an information-intensive business generating huge volumes of data from hospitals, primary care surgeries, clinics, and laboratories. Yet much of this data continues to be processed manually in spite of decades of experience in the successful application of information technology (IT) in other information-intensive industries. There are a number of reasons for this...

Chronic obstructive pulmonary disease (COPD) with severe emphysema is a continuously progressing disease, resulting in respiratory failure. Pharmacological treatment may be optimised in the last years, but only the introduction of long-term oxygen treatment has revealed an improvement in survival for patients with advanced COPD [1]. Noninvasive positive pressure ventilation (NPPV) is a new appr...

For more than four decades, a movement to shift cannabis control policy away from prohibition has gained momentum in such countries as Australia, Netherlands, Portugal, Spain, and the United States (Caulkins et al., 2012, pp. 207–224). When the issue is debated, researchers, and clini-cians in the addictive behaviors field may face a difficult choice when asked where they stand with reference t...

brief battle with cancer. His passing has created an irretrievable loss for the field of cardiovascular medicine, because he was the essence of a clinician-teacher-investigator. Kanu was soft-spoken, kind, and wise; he was a practitioner of extraordinary skill, and spiritual. We were privileged to know this gentle giant of cardiology. while still living in a refugee camp in Calcutta. He moved t...