Background: Currently immune checkpoint pathways of PD1-PD-L1 is being used to treat lung cancer and PD-L1 served as predictive biomarker. Investigations expression a target immunotherapy in specimens Indonesia needed. This study aimed evaluate resected using immunohistochemistry techniques. Methods: Thirty surgically sample from patients were obtained. The whole stained by techniques automatic...

A clinicopathological analysis was made of I3 cases in which the anatomical characteristics of tetralogy of Fallot were associated either with the classicalfeatures of the complete type of persistent common atrioventricular canal (8 cases) or with a forme fruste of the latter (5 cases); that is, cleft tricuspid valve (4 cases) and isolated ostium primum (one). The ratio offemale to male was IO ...

Objective(s):Previous studies demonstrate that changes in pre-mRNA splicing play a significant role in human disease development. Furthermore, many cancer-associated genes are regulated by alternative splicing. There are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. Located on the X chromosome, ...

We examined the expression of angiopoietin-2 in serum samples from patients diagnosed with colorectal cancer and healthy volunteers and investigated the feasibility of using angiopoietin-2 as a potential diagnostic colorectal cancer biomarker. Enzyme-linked immunosorbent assays were used to measure the levels of angiopoietin-2 in patients with colorectal cancer and healthy control subjects. Cor...

BACKGROUND Non-small cell lung cancer (NSCLC) in young patients is uncommon and is thought to constitute a distinct oncological entity with characteristic clinicopathological patterns. Since the reported data are scant and discordant, the presentation, management and outcome data of NSCLC patients aged under 45 years of age were analyzed and compared with those of patients over 45 years old. Pr...

background: the lysosomal protease cathepsin d (cd) has been associated with tumor progression in malignant tumors including oral squamous cell carcinoma (oscc). the purpose of this study was to find out any association between the cd and lymph node metastasis and to study the correlation of cd with various clinicopathological parameters to aid in assessment of its role as a prognostic indicato...

A 53-year-old man was admitted to Keio University Hospital because of serious dyspnea and edema of the lower extremities. Eighteen months previously, the patient had complained of chest discomfort, and was then admitted for the first time to our hospital for evaluation of chest pain. Electrocardiography showed poor R wave progression in leads Vl through V4, and diffuse nonspecific STsegment and...

It is a challenging task to diagnose mycosis fungoides (MF), a type of primary cutaneous lymphoma, in the early stages of its development, due to the unspecific presentations associated with the disease. Histopathology and immunohistochemistry conduce to a more definite diagnosis. Presence of atypical T-cells in epidermis and upper dermis is the most significant pathologic finding. Herein...

Abstract Background Differentiated thyroid carcinoma (DTC) is the most common malignant tumor of endocrine system. Our study aimed to investigate role α- and γ-Klotho genes in development progression DTC. Methods The expression was assessed by quantitative real-time polymerase chain reaction (RT-qPCR) tissues 40 DTC patients age- sex-matched subjects diagnosed as goiter included a control group...

In patients with colorectal cancer (CRC), the BRAF V600E mutation has been reported to be associated with several clinicopathological features and poor survival. However, the prognostic implications of BRAF V600E mutation and the associated clinicopathological characteristics in CRCs remain controversial. Therefore, we reviewed various clinicopathological features, including BRAF status, in 349...