A number of inhibitors of the essential Mycobacterium tuberculosis mycolic acid transporter, MmpL3, are currently under development as potential novel antituberculosis agents. Using the checkerboard method to study the interaction profiles of various antituberculosis drugs or experimental compounds with two different chemotypes inhibiting this transporter (indolcarboxamides and adamantyl ureas)...

Multidrug-resistant tuberculosis (MDR-TB) is a major public health challenge, with an estimated 480000 new cases emerging globally each year [1]. Treatment success rates using the 20-month conventional World Health Organization (WHO) regimen have been low, being about 52% in 2013 [1]. Observational studies in Bangladesh and several African countries have shown success rates of 84% using a short...

Although numerous antimicrobial agents have been used to treat disseminated Mycobacterium avium complex (MAC) infection, the optimal therapy for this disease is unknown. One potentially effective agent is rifabutin, which has demonstrated activity against MAC both in vitro and in animal models of infection. In clinical trials, cultures of blood from 46% to 92% of patients become sterile after t...

The ALERT Leprosy Control Programme introduced WHOIMDT in Ethiopia in January 1 983 . Paucibacillary patients are treated for 6 months with self-administered daily dapsone and rifampicin once monthly under supervision. Multibacillary patients are treated for a period of at least 2 years or until the skin smears become negative. Treatment consists of self-administered dapsone, clofazimine and ri...

Traditionally, patients with rifampicin-resistant (RR) or multi-drug resistant tuberculosis (MDR-TB) are treated with a combination of second-line drugs, usually for 18 months or more [1]. Recently, World Health Organization (WHO) recommended a shorter and cheaper treatment regimen for MDR-TB [2]. Standardized shorter MDR-TB regimen consists of seven drugs and a treatment duration of 9-12 month...

The activity of seven antimicrobial agents (and five two-drug combinations and five three-drug combinations) was investigated against 37 clinical isolates of Mycobacterium avium recovered from blood cultures of AIDS patients. The susceptibility tests were performed in Middlebrook 7H12 broth using a radiometric method. MICs of amikacin, ciprofloxacin, clarithromycin, clofazimine, ethambutol, rif...

An open trial to assess the value of c10fazimine in the management of cases of lepromatous leprasy with recurrent lepra reaction and those who are sulphone sensitive was commenced in February, 1 9 7 3 . Thalidomide was used as the drug in the contrai subjects. U p to the end of August, 1 9 74 , 6 1 cases have been ad mitted into the study. In the majority of instances the drug had been found to...