Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is approximately 4x less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whether this difference in repair efficiency involves XRCC1 or other BER proteins, synthetic oligonucleoti...

in april, 2013, a suzhou hospital reported a nitrite intoxication patient in coma as well as 2 family members with the similar symptom 5 days ahead. we investigated the event to identify the cause, source and possible pollution ways of the contamination.we defined case as any person living in yshy community who has cyanosis and with at least one of the following symptoms: dizziness, headache, f...