We describe a two- year old boy who was diagnosed with pre-B acute lymphoblastic leukemia (ALL). He developed a central nervous system (CNS) relapse with optic nerve involvement. Initially he was treated according to the ALL relapse protocol, including CNS radiotherapy. Despite an initial complete reponse, relapse occurred within six weeks of treatment. The leukemic blast cells were CD-20 posit...

Haluk Demiroğlu, Hacettepe Universitesi Tip Fakültesi, Hematoloji Departmant, TR-06100 Ankara (Turkey) A case of acute lymphoblastic leukaemia (ALL) presenting with an intraspinal mass was described by Hwang et al. [1] in this journal, thus adding another unusual extrame-dullary (EM) site of relapse in this disease. We report an ALL patient with an isolated ovarian relapse and cutaneous involve...

Improved treatment for acute lymphoblastic leukemia (ALL) has virtually eliminated testicular relapse. However, the control of central nervous system (CNS) leukemia remains a therapeutic challenge in childhood ALL, partly because of the late complications arising from cranial irradiation. In most current pediatric protocols, cranial irradiation (12 to 18 Gy) is given to 5% to 25% of patients--t...

Introduction: Central Nervous System (CNS) involvement in Diffuse Large B Cell Lymphoma (DLBCL) is a rare complication associated with bad prognosis. The CNS Prognostic Index identifies patients high risk of relapse; however, its specificity limited and not accurate. Biomarkers that can predict relapse are still missing. For reason, we aimed to characterize the transcriptomic, genomic epigenomi...

Lymphoma with secondary central nervous system (CNS) involvement have poor prognosis and high mortality. Its diagnosis is based on conventional methods low sensitivity and/or specificity. MicroRNAs are short post-transcriptional gene regulators that remarkably stable detectable extracellularly in body fluids. We analyzed circulating microRNAs the cerebrospinal fluid (CSF) plasma of 162 patients...

Seventy-four children with acute lymphoblastic leukaemia had one or more episodes of central nervous system (CNS) leukaemia. 5 children had CNS involvement at diagnosis; 4 survived for less than one year. In 35 children who had not had a previous bone marrow relapse on treatment and who received combination chemotherapy, the median duration of haematological remission from the time of first CNS...

Acute promyelocytic leukaemia (APML) is a condition classically characterised by t(15;17) (q22, q21), with disseminated intravascular coagulopathy (DIC) being a major cause of death. Central nervous system (CNS) involvement with APML commonly occurs in relapse; however, it is rarely seen at presentation, with only six reported cases in the literature. This case is the first to describe a patien...